Villiers was born on 14 December 1757, the second son of Lady Charlotte, daughter of William Capel, 3rd Earl of Essex, and Thomas Villiers, 1st Earl of Clarendon. He was educated at Eton and St John's College, Cambridge and graduated with an MA in 1776 and an LL.D on 30 April 1833. He was called to the bar at Lincoln's Inn on 22 June 1779. In January 1784 Lord Camelford brought Villiers into Parliament at a by-election for Old Sarum, and he represented that rotten borough until 1790, and then sat for Dartmouth 1790–1802, and for the Tain Burghs from 1802 until 27 May 1805, when he accepted the Chiltern Hundreds. He was afterwards member for Queenborough 1807–1812 and 1820–1824. Villiers did not make his mark in Parliament as a debater, and was styled "a mere courtier, famous for telling interminable long stories". The Rolliad notices him as "Villiers, comely with the flaxen hair", and likens him to the Nereus of Homer. Sir Nathaniel Wraxall also styles him the "Nereus" of Pitt's forces, and mentions him as a staunch supporter of that minister, to whose friendship entirely he owed his appointment for life in February 1790 to the lucrative sinecure of warden and chief justice in eyre of all the royal forests, chaces, parks, and warrens north of Trent. On 6 February 1782 Villiers was made joint King's Counsel in the Duchy Court of Lancaster by his father, who then was Chancellor of the Duchy. From 29 July 1786 until his succession to the peerage he was Surveyor of Woods south of the Trent of the Duchy of Lancaster. He was added to the Privy Council and made Comptroller of the King's Household on 19 February 1787. This position at court he filled for three years, and on 24 February 1790 he was made a Commissioner of the Board of Trade. He was Recorder and Under-Steward of New Windsor from 1789 to 1806. When the rise of the French Republic caused apprehensions in Britain, Villiers was appointed colonel of the First Regiment of Fencible Cavalry on 14 March 1794, and was granted the rank of colonel in the army during service in the field. He was made first Prothonotary of the Common Pleas in the County Palatine of Lancaster in June 1804, and held the office until his death. From 27 November 1808 to 10 January 1810 Villiers was envoy to the court of Portugal. On the death of his eldest brother, Thomas, unmarried, on 7 March 1824, he succeeded him as 3rd Earl of Clarendon and as a count of the Kingdom of Prussia, but took little part afterwards in public life, devoting himself to religious and charitable works. He died suddenly, aged 81, at his residence, Walmer Terrace, Deal, Kent on 22 December 1838, and was buried at Watford on 29 December. Villiers was succeeded in the earldom by his nephew, George Villiers, who became a distinguished Liberal statesman.