On 12 August 1831, in Cincinnati, Ohio, he married Elizabeth Ramsey Irwin. He and Elizabeth had 10 children:
Archibald Harrison
Benjamin Harrison ; became president
Mary Jane Harrison
Anna Symmes Harrison
John Irwin Harrison
Carter Bassett Harrison
Anna Symmes Harrison
John Scott Harrison Jr.
James Findlay Harrison
James Irwin Harrison
After his father's death, in 1841, his mother moved in with his family to help raise the children.
Political career
He was elected a Whig to the U.S. House of Representatives in 1852, reelected an Oppositionist in 1854 and served from 1853 to 1857. After being defeated for a third term in 1856, Harrison retired to his estate "Point Farm" in North Bend, Ohio where he died on May 25, 1878. He was the last surviving child of William Henry Harrison. He was interred in the family tomb in North Bend, today the William Henry Harrison Tomb State Memorial, with his parents and other family members. Harrison's body was stolen by grave robbers until it was eventually returned to its final place of rest.
Body snatching
At that time it was common practice for graves to be robbed for recently deceased bodies for use in teaching dissection and anatomy at medical colleges. As a result, many precautions were taken to secure Harrison's grave, including building a cemented brick vault, filling the grave with earth mixed with heavy stones, and employing a watchman to check the grave each hour of every night for a week. The day of Harrison's funeral it was discovered that the body of Augustus Devin, which had been buried the previous week in an adjoining grave, had been stolen. The following day, one of John Harrison's sons, together with a friend of Devin, traveled to Cincinnati to look for his body. With search warrants in hand they went to the Ohio Medical College, where they discovered not Devin's body but the naked body of John Scott Harrison hanging from a rope down a chute beneath a trap door. Devin's body was later found preserved in a vat of brine at the medical college of the University of Michigan. The outrage over the act, amid changing sensibilities regarding death, contributed materially to passage of the Ohio Anatomy Law of 1881, a landmark statute, whereby medical schools were provided with unclaimed bodies, which in turn discouraged grave robbers by removing their primary market. As to the personal results, suits were brought against the Ohio Medical College; the Harrison estate was entered in a separate damage suit, in the amount of $10,000. The end result and decision in the three civil suits brought, has been lost in the passage of time, and no documentation is known to exist with this specific information.