Murray was the son of John Murray, 1st Earl of Atholl by his wife Jane, daughter of Sir Duncan Campbell of Glenorchy. In 1650 he joined in the unsuccessful attempt to liberate Charles II from the Covenanters, and he was, in 1653, a chief supporter of the 8th Earl of Glencairn's rising to power in opposition to English plans to incorporate Scotland into the Commonwealth and devoted 2,000 men to the battle. He was eventually obliged to surrender the following year to George Monck, the victorious Commonwealth commander.
Murray was initially a supporter of the robust policies of Lord Lauderdale, taking part in a 1678 raid against the Covenanters, but he then temporarily lost royal favour by counselling moderation concerning the measures taken against them. In 1679, however, he was present at the Battle of Bothwell Bridge; in July 1680 he was made vice-admiral of Scotland, and in 1681 president of parliament. In 1684 he was appointed lord-lieutenant of Argyll, fought vigorously against the 9th Earl of Argyll in Argyll's Rising of 1685 and was instrumental in defeating him. Murray was knighted in 1687. He showed himself to be lukewarm to the accession of William III and waited on the event. Finally in April 1689 he wrote to William to declare his allegiance, and in May took part in the proclamation of William and Mary as king and queen at Edinburgh. But during Viscount Dundee's insurrection he allowed his troops to be used at the Battle of Killiecrankie against the supporters of the new king, which helped bring about the defeat of the government's troops. He was then summoned to London and imprisoned during August. In 1690 he was implicated in the Montgomery plot to restore James and subsequently in further Jacobite intrigues. In June 1691 he received a pardon, and acted later for the government in the pacification of the Highlands. Ironically, given Murray's rumoured Jacobite leanings but public opposition to the group, his grandson, Lord George Murray became a famed general of the Jacobites and was responsible for their success throughout the greater part of the 1745 uprising. Murray was described by Lord Macaulay as "the falsest, the most fickle, the most pusillanimous of mankind", regarding Murray's indecisive position surrounding the succession of William of Orange and the deposition of King James."
Sir Mungo Murray, Bt., Scotland; Killed in Panama 1700, fighting the Spanish. Married Rachel Beaverich; son David married Margaret Donald; two daughters. Scotland, Select Marriages, 1561–1910, FHL Film # 1040174 22 Feb 1695, St. Andrews And St. Leonards,Fife,Scotland shows marriage to Rachell Beavrich. Possibility of 2 children, 1 male, David, and 1 female, Catherine.
Lord Edward Murray, married Katherine Skene.
Lord Henry Murray, died young.
Lady Katherine Murray, died young.
Lord George Murray, died young.
Prior to his marriage with Amelia Sophia Stanley one "natural son" was born c. 1658 to Janett Mannachie from Dunkeld Perthshire. This son's name is unknown; however he is stated to have been apprenticed to an Edinburgh Lawyer by the name of Louefoote. According to correspondence from the above-mentioned Lord Edward Murray born 1669 and reproduced in the Atholl Chronicles-dated March 25, 1735 addressed to his nephew John 1st Duke of Athol, this son died of smallpox c. 1680–90. The same source records: Jane Murray born 1676 c- twin, & Male Murray- born 1676c- twin born Castle Tullibardine Perthshire and lived in France. m. 1. Captain Anderson ; m. 2. Mr Ongolling; m3. James Mazel. Also possibly:
William Murray c. 1658–1725, remained in Scotland and married Mary Vans; son William Vans Murray died 1763 in Maryland.