Vázquez was born in Ferrol, Galicia. He moved to Melilla, where he joined as an undergraduate at the localVeterinary School; however, before he could complete his studies he moved to Madrid. In this period he worked as model. Vázquez rose to fame in the early 1990s as the host of two television shows aimed at the teenage audience aired on Telecinco: La quinta marcha, which he hosted alongside Penélope Cruz, and Hablando se entiende la basca. In this period he starred in the film Aquí el que no corre, vuela., directed by Ramón Fernández and produced by Telecinco, along with Alfredo Landa, Arturo Fernández, Arancha del Sol and Natalia Estrada. In 1993 he ventured into singing with the albumA dos milímetros escasos de tu boca, which achieved a Gold Record certificate; however, his music career did not have continuity. In 1998 Vázquez presented A propósito, on Canal Sur and the game show with celebrities Gente con chispa, aired on regional televisions. In 2000, he hosted the short-lived late night show La central on Antena 3, cancelled due to poor ratings. In 2001, he was hired by Telemadrid to host talk showÉsta es mi gente. In 2002, he combined this work with presenting talent showPopstars: Todo por un sueño on Telecinco. In 2003 Vázquez left Telemadrid to present talk show Nadie es perfecto on Telecinco; the show was cancelled after three weeks. In 2003, also on Telecinco, he presented the weekly debate show of Gran Hermano, as well as reality television seriesHotel Glam and Vivo Cantando. In 2004 and 2005, Vázquez hosted the first two seasons of Gran Hermano VIP. Subsequently, he hosted reality-show talent contest reality-show talent contest Operación Triunfo from 2005 to 2008, and the Spanish version of Survivor from 2006 to 2010. In addition, he presented daily game show ¡Allá tú! from 2004 to 2008. Apart from Operación Triunfo and Survivor, in 2007 Vázquez hosted reality show Nadie es perfecto, and in 2009, game shows Guerra de sesos alongside Almudena Cid, and Mi familia contra todos. In 2010 the last seasons Operación Triunfo and Survivor that featured Vázquez aired and he presented reality dating show I Love Escassi. When Telecinco and Cuatro merged into Mediaset España in 2011, it was decided that Vázquez would become a visible face of Cuatro. In Cuatro he hosted game show Uno para ganar and the fourth season of reality television game showPekín Express. In 2012, Vázquez moved back to Telecinco to host La Voz. Since then he has also hosted talent showsLa Voz Kids, Pequeños Gigantes, Levántate, Me lo dices o me lo cantas and Factor X. In 2016, Vázquez joined Got Talent España on its first season as one of the four judges. In 2017, Vázquez hosted Proyecto Bullying, a docu-show that centered on school bullying that will air on Cuatro.