The year after the war ended, he was appointed president of the brewery by his father after the death of his predecessor, Arthur Deute. Under the younger Hoffberger's command, National's sales rose from 230,000 barrels in 1946 to two million in 1966.
In 1953, when the St. Louis Browns of baseball's American League wanted to move to Baltimore, the nearby Washington Senators, led by Clark Griffith, objected to the potential encroachment on their market. Hoffberger helped ease the way for the move by making his National Bohemian beer a Senators sponsor. When Browns owner Bill Veeck was all but forced to sell the team, Hoffberger and attorney Clarence Miles put together a syndicate that bought the team for $2.5 million and moved it to Baltimore as the Orioles. Hoffberger was the largest single shareholder in the Orioles, but was initially a silent partner with Miles, James Keelty and Joe Iglehart. During this time, however, he bought more and more stock until he acquired controlling interest in 1965. He immediately brought in Frank Cashen, National's advertising director, as executive vice president. Under the direction of Cashen and general managerHarry Dalton, the Orioles won four AL pennants and two World Series from 1966 to 1971. Even though the Orioles were a success on the diamond, the team struggled financially because of lagging attendance. Looking to sell his ballclub and brewery, Hoffberger engaged in talks for three months with the Labatt Brewing Company which was attempting to attract a major-league franchise to move to Toronto. Negotiations ended when the National and Carling Brewing Companies agreed to a merger on October 14, 1975. A result of the consolidation was Hoffberger becoming chairman and chief executive officer of the newly formed Carling National Breweries, Inc. He retained ownership of the Orioles which wasn't included in the transaction, but couldn't sell it without company approval. Hoffberger cast the lone dissenting ballot when the American League club owners voted to award the Toronto expansion franchise to an investment group led by Labatt's. He had arranged the only other competing bid which was fronted by Atlantic Packaging Company chairman of the board Phil Granovsky and had the potential financial support from Carling's advertising money, but the attempt wasn't successful due to the Labatt's group having nearly purchased the San Francisco Giants with the intention of transferring it to Toronto. Hoffberger stated, "It was just not in the best interests of my company for Labatt’s to get the franchise." He was a 1996 honoree into the Orioles Hall of Fame, inducted with Cal Ripken, Sr. and Billy Hunter. 400 showed up at the luncheon at the Sheraton Inner Harbor Hotel. When Baltimore Oriole star Frank Robinson was inducted into the Baseball Hall of Fame in 1982, he made reference to Hoffberger. He said that after a game, Hoffberger "wouldn't come over and slap you on the back and say nice game-winning home run, nice double, nice play or whatever. The first words out of his mouth were: 'How are you? How's your family? Is there anything I can do for you?'."