Jatrorrhizine


Jatrorrhizine is a protoberberine alkaloid found in some plant species, such as Enantia chlorantha. Synonyms that may be encountered include jateorrhizine, neprotin, jatrochizine, jatrorhizine, and yatrorizine.

Bioactive effects

Jatrorrhizine has been reported to have antiinflammatory effect, and to improve blood flow and mitotic activity in thioacetamide-traumatized rat livers. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits monoamine oxidase It interferes with multidrug resistance by cancer cells in vitro when exposed to a chemotherapeutic agent. Large doses reduced blood sugar levels in mice by increasing aerobic glycolysis.
Derivatives of jatrorrhizine have been synthesized and found to have much stronger antimicrobial effects.