Wood-Mason was born in Gloucestershire, England, where his father was a doctor. He was educated at Charterhouse School and Queen's College, Oxford. He went out to India in 1869 to work in the Indian Museum, Calcutta, which in 2008 still housed his collection of insects. In 1872 he sailed to the Andaman Islands, mostly studying marine animals, but also collecting and later describing two new phasmids, Bacillus hispidulus and Bacillus westwoodii. Wood-Mason described 24 new species of phasmids, mostly from South Asia but also some from Australia, New Britain, Madagascar, the Malay peninsula and Fiji. His naming of Cotylosoma dipneusticum is particularly curious as he never formally described the species; it was wrongly imagined to be semi-aquatic; it was "described with what is probably the least precise measurement ever used for a phasmid", namely ""between three and four inches in length"; and he gave its locality as Borneo, when in fact it came from Fiji. In 1887 he became Superintendent of the Indian Museum. Also in 1887, he became vice-president of the Asiatic Society of Bengal. In 1888 he sailed on the Indian Marine Survey steamship, working on and later describing new species of Crustacea, along with Alfred William Alcock, who recorded the voyage in his classic natural history book A Naturalist in Indian Seas. For several years he suffered from Bright's disease. On 5 April 1893, unable to work, he left India for England, but died at sea on 6 May 1893.
Wood-Mason was a Fellow of the Royal Entomological Society. In 1888 he became a Fellow of the University of Calcutta. Over 10 marine animals have the specific name woodmasoni in his honour, including several described by Alcock of the Investigator : Heterocarpus woodmasoni, Coryphaenoides woodmasoni, Thalamita woodmasoni, and Rectopalicus woodmasoni. Two species of snake are named in his honour: Oligodon woodmasoni and Uropeltis woodmasoni.
A Catalogue of the Mantodea, with descriptions of new genera and species, and an enumeration of the specimens. Printed by order of the Trustees of the Indian Museum, 1889.
On the uterine villiform papillae of Pteroplataea micrura, and their relation to the embryo, being natural history notes from H.M. Indian marine survey... R.F. Hoskyn, R.N., commanding. Harrison and Sons, 1891.
Further observations on the gestation of Indian rays: Being natural history notes from H.M. Indian marine survey steamer 'Investigator', Commander R.F. Hoskyn, R.N., commanding. Harrison and Sons, 1892.
. Calcutta. Published by order of the trustees of the Indian Museum, 1895.