In the 2011–12 season, Lowe scored 19 goals for Barnet's under-18 team. He made his senior debut on 25 August 2012, in a 3–1 loss against York City at Underhill, coming on as a late substitute for Curtis Weston. After making a second substitute appearance against Gillingham, he was given his first start by manager Mark Robson on 15 September in a 3–0 loss against Bradford City. Lowe signed a professional contract with the Bees in October 2012. He made his FA Cup debut on 3 November, coming on as a substitute in the second half of a 2–0 defeat against Oxford United in the first round. In December 2012, he was loaned out to Hayes & Yeading United. He joined Boreham Wood on 15 February 2013. On 15 August 2013, Lowe joined Hitchin Town on loan. His fourth loan spell away from the club began when he joined St Albans City on 22 November. Then, his fifth loan spell came when he joined Farnborough on 28 February 2014. Lowe was transfer-listed at the end of the 2013–14 season. Manager Martin Allen said: "He is a good lad who has worked hard and done well in both the games he has played but I need tobring in another striker and this will push Jamal further down the line". In 2014–15, Lowe made two substitute appearances for the Bees before joining Hemel Hempstead Town on a three-month loan. On 16 January 2015, he left Barnet permanently to join St Albans City. At the end of the season he rejoined Hemel Hempstead Town. After 11 league games he then joined Hampton & Richmond Borough.
On 28 October 2016, Portsmouth agreed terms to sign Lowe for an undisclosed fee on an 18-month contract. On the 17 April 2017, Lowe scored a 13-minute brace at Notts County; the day which Portsmouth clinched promotion to League One. On the last day of the 2016/17 season, Lowe scored a goal to help Pompey to a 6–1 victory over Cheltenham and the League Two title. In January 2018 Lowe signed a new contract keeping him at Fratton Park until 2021. In the 2018–19 season Lowe was Kenny Jackett's first choice right-winger, seeing off competition from summer signing Louis Dennis in which he was able to score 9 goals before the turn of the year. On 31 March 2019, Lowe featured in Portsmouth's Checkatrade Trophy final against Sunderland A.F.C., and in the 114 minute, he chipped the ball over Jon Mclaughlin and seemingly scored the winning goal - however, Sunderland equalized in the last minute of extra time. The game went to penalties and Lowe scored the fourth of five for Portsmouth. Former Hemel Hempstead Town teammate Oliver Hawkins went on to score the winning penalty for Portsmouth.
Wigan Athletic
On 1 August 2019, Lowe signed a three-year contract with Wigan Athletic for an undisclosed fee. He scored his first goal for the club on 20 October 2019 against Nottingham Forest.
Personal life
Lowe worked as a PE teacher while playing in non-league football.
