In 1937 Clark became the curator of Northern Rhodesia's Rhodes-Livingstone Museum. A year later he married Betty Cable née Baume, who would accompany him on a number of expeditions throughout his life. Clark served in the military during World War II with the East Africa Command forces in Somalia and Ethiopia, being subsequently attached to the British Military Administration, when he managed to find time to carry out archaeological fieldwork in the Horn of Africa. Following the war, he returned to Cambridge, completing his PhD in 1947. In 1948 he founded the Northern Rhodesian National Monuments Commission. Clark then returned to Northern Rhodesia to serve once more as the Museum's director. In 1953, Clark ordered an excavation at Kalambo Falls, a 235m high, single-drop waterfall at the southeast end of Lake Tanganyika, on what is now the border between Zambia and Tanzania. The site would eventually emerge as one of the most important archaeological finds of the twentieth century, providing a record of more than two hundred and fifty thousand years of human history. To date, artefacts of Acheulean, Sangoan, Lupemban, Magosian, Wilton, and Bantu cultures have all been found at the falls. Clark also undertook significant fieldwork in Ethiopia, Somalia, Malawi, Angola, and Niger, some of which led him to collaborate with Louis and Mary Leakey. In 1961, Clark resigned from his post as Director of the Museum, and became Professor of Anthropology at the University of California, Berkeley, where he taught until his retirement in 1986. Under his guidance, the programme became one of the world's foremost in paleoanthropology. In 1965, he was elected a Fellow of the American Academy of Arts and Sciences. He received the Gold Medal Award for Distinguished Archaeological Achievement in 1988 from the Archaeological Institute of America. Clark continued working until his death, including a 1991 dig in China that was the first to be led in that country by foreign archaeologists in more than 40 years. Clark died of pneumonia in Oakland in 2002, having published more than twenty books and over 300 scholarly papers on paleoanthropology and African prehistory in the course of his career. His wife survived him by only two months. He is survived by his children, Elizabeth and John. Over the course of his career, Clark compiled a large scholarly library of scientific books and articles which he donated to his former students, archaeologists Nicholas Toth and Kathy Schick, at the Stone Age Institute where the collection is now housed as the Desmond Clark Memorial Library.