Isoxazole


Isoxazole is an azole with an oxygen atom next to the nitrogen. It is also the class of compounds containing this ring. Isoxazolyl is the univalent radical derived from isoxazole.

Occurrence

Isoxazole rings are found in some natural products, such as ibotenic acid and muscimol.

Pharmaceuticals and herbicides

Isoxazoles also form the basis for a number of drugs, including the COX-2 inhibitor valdecoxib and a neurotransmitter agonist AMPA. A derivative, furoxan, is a nitric oxide donor. An isoxazolyl group is found in many beta-lactamase-resistant antibiotics, such as cloxacillin, dicloxacillin and flucloxacillin. Leflunomide is an isoxazole-derivative drug. Examples of AAS containing the isoxazole ring include danazol and androisoxazole. A number of pesticides are isoxazoles.
is an example of an isoxazole used as a herbicide.