Isothiouronium
In organic chemistry, isothiouronium is a functional group with the formula + and is the acid salt of isothiourea. The H centres can also be replaced by alkyl and aryl. Structurally, these cations resemble guanidinium cations. The CN2S core is planar and the C-N bonds are short.Synthesis
Salts comprising these anions are typically prepared by alkylation of thiourea:Reactions
of isothiouronium salts gives thiols.
Isothiouronium salts in which the sulfur has been alkylated, such as S-methylisothiourea hemisulfate, will convert amines into guanidinium groups. This approach is sometimes called the Rathke synthesis after Bernhard Rathke who first reported it in 1881.
Chelating resins with isothiouronium groups are used to recover mercury and noble metals including platinum from solutions.
