Intragenomic conflict refers to the evolutionary phenomenon where genes have phenotypic effects that promote their own transmission in detriment of the transmission of other genes that reside in the same genome. The selfish gene theory postulates that natural selection will increase the frequency of those genes whose phenotypic effects cause their transmission to new organisms, and most genes achieve this by cooperating with other genes in the same genome to build an organism capable of reproducing and/or helping kin to reproduce. The assumption of the prevalence of intragenomic cooperation underlies the organism-centered concept of inclusive fitness. However, conflict among genes in the same genome may arise both in events related to reproduction and altruism.
Nuclear genes
genes usually have the same mode of transmission in sexually reproducing species due to the fairness of Mendelian segregation, but conflicts among alleles of autosomic genes may arise when an allele cheats during gametogenesis or eliminates embryos that don't contain it. An allele may also directly convert its rival allele into a copy of itself. Finally, mobile genetic elements completely bypass Mendelian segregation, being able to insert new copies of themselves into new positions in the genome.
Segregation distortion
In principle, the two parental alleles have equal probabilities of being present in the mature gamete. However, there are several mechanisms that lead to an unequal transmission of parental alleles from parents to offspring. One example is a gene, called a segregation distorter, that "cheats" during meiosis or gametogenesis and thus is present in more than half of the functional gametes. The most studied examples are sd in Drosophila melanogaster, t haplotype in Mus musculus and sk in Neurospora spp.. Possible examples have also been reported in humans. Segregation distorters that are present in sexual chromosomes are denominated sex-ratio distorters, as they induce a sex-ratio bias in the offspring of the carrier individual.
Killer and target
The most simple model of meiotic drive involves two tightly linked loci: a Killer locus and a Target locus. The segregation distorter set is composed by the allele Killer and the allele Resistant, while its rival set is composed by the alleles Non-killer and Non-resistant. So, the segregation distorter set produces a toxin to which it is itself resistant, while its rival is not. Thus, it kills those gametes containing the rival set and increases in frequency. The tight linkage between these loci is crucial, so these genes usually lie on low-recombination regions of the genome.
True meiotic drive
Other systems do not involve gamete destruction, but rather use the asymmetry of meiosis in females: the driving allele ends up in the oocyte instead of in the polar bodies with a probability greater than one half. This is termed true meiotic drive, as it does not rely on a post-meiotic mechanism. The best-studied examples include the neocentromeres of maize, as well as several chromosomal rearrangements in mammals. The general molecular evolution of centromeres is likely to involve such mechanisms.
The Medea gene causes the death of progeny from a heterozygous mother that do not inherit it. It occurs in the flour beetle. Maternal-effect selfish genes have been successfully synthesized in the lab.
Transposons
are autonomous replicating genes that encode the ability to move to new positions in the genome and therefore accumulate in the genomes. They replicate themselves in spite of being detrimental to the rest of the genome. They are often called 'jumping genes' or parasitic DNA and were discovered by Barbara McClintock in 1944.
convert their rival allele into a copy of themselves, and are thus inherited by nearly all meiotic daughter cells of a heterozygote cell. They achieve this by encoding an endonuclease which breaks the rival allele. This break is repaired by using the sequence of the HEG as template. HEGs encode sequence-specific endonucleases. The recognition sequence is 15–30 bp long and usually occurs once in the genome. HEGs are located in the middle of their own recognition sequences. Most HEGs are encoded by self-splicing introns and inteins. Inteins are internal protein fragments produced from protein splicing and usually contain endonuclease and splicing activities. The allele without the HEGs are cleaved by the homing endonuclease and the double-strand break are repaired by homologous recombination using the allele containing HEGs as template. Both chromosomes will contain the HEGs after repair.
B-chromosome
s are nonessential chromosomes; not homologous with any member of the normal chromosome set; morphologically and structurally different from the A's; and they are transmitted at higher-than-expected frequencies, leading to their accumulation in progeny. In some cases, there is strong evidence to support the contention that they are simply selfish and that they exist as parasitic chromosomes. They are found in all major taxonomic groupings of both plants and animals.
Cytoplasmic genes
Since nuclear and cytoplasmic genes usually have different modes of transmission, intragenomic conflicts between them may arise. Mitochondria and chloroplasts are two examples of sets of cytoplasmic genes that commonly have exclusive maternal inheritance, similar to endosymbiont parasites in arthropods, like Wolbachia.
Males as dead-ends to cytoplasmic genes
generally produces zygotes that inherit cytoplasmic elements exclusively from the female gamete. Thus, males represent dead-ends to these genes. Because of this fact, cytoplasmic genes have evolved a number of mechanisms to increase the production of female descendants and eliminate offspring not containing them.
Feminization
Male organisms are converted into females by cytoplasmic inherited protists or bacteria, regardless of nuclear sex-determining factors. This occurs in amphipod and isopodCrustacea and Lepidoptera.
Male-killing
Male embryos or male larvae are killed. In the case of embryo death, this diverts investment from males to females who can transmit these cytoplasmic elements. In the case of microsporidia-induced larval death, the agent is transmitted out of the male lineage into the environment, where it may be taken up again infectiously by other individuals. Male-killing occurs in many insects. In the case of male embryo death, a variety of bacteria have been implicated, including Wolbachia.
Male-sterility
In some cases anther tissue is killed by mitochondria in monoeciousangiosperms, increasing energy and material spent in developing female gametophytes. This leads to a shift from monoecy to gynodioecy, where part of the plants in the population are male-sterile.
Parthenogenesis induction
In certain haplodiploidHymenoptera and mites, in which males are produced asexually, Wolbachia and Cardinium can induce duplication of the chromosomes and thus convert the organisms into females. The cytoplasmic bacterium forces haploid cellsto go through incomplete mitosis to produce diploid cells which therefore will be female. This produces an entirely female population. If antibiotics are administered to populations which have become asexual in this way, they revert to sexuality instantly, as the cytoplasmic bacteria forcing this behaviour upon them are removed.
Cytoplasmic incompatibility
In many arthropods, zygotes produced by sperm of infected males and ova of non-infected females can be killed by Wolbachia or Cardinium.
Evolution of sex
Conflict between chromosomes has been proposed as an element in the evolution of sex.
