Insulin lispro, sold under the brand name Humalog among others, is a type of insulin used to treat type 1 and type 2 diabetes. Typically it is taken around the time of eating. It is used by injection under the skin or within an insulin pump. Onset of effects typically occurs within 30 minutes and lasts about 5 hours. Often a longer acting insulin like NPH is also needed. Common side effects include low blood sugar. Other serious side effects may include low blood potassium. Use in pregnancy and breastfeeding is generally safe. It works the same as human insulin by increasing the amount of glucose that tissues take in and decreasing the amount of glucose made by the liver. Insulin lispro was first approved for use in the United States in 1996. It is a manufactured form of human insulin where an amino acid has been switched. In the United Kingdom it costs the NHS about per 100 units as of 2019. In the United States the wholesale cost of this amount is about. In 2017, it was the 124th most commonly prescribed medication in the United States, with more than six million prescriptions.
Medical uses
Insulin lispro is used to treat people with type 1 diabetes or type 2 diabetes. People doing well on regular insulin should not generally be changed to insulin lispro.
Do not administer insulin lispro during episodes of hypoglycemia, or if a person has a hypersensitivity to insulin lispro or any of its excipients.
Mechanism of action
Through recombinant DNA technology, the final lysine and proline residues on the C-terminal end of the B-chain are reversed. This modification does not alter receptor binding, but blocks the formation of insulin dimers and hexamers. This allows larger amounts of active monomeric insulin to be immediately available for postprandial injections.
Chemistry
It is a manufactured form of human insulin where the amino acids lysine and proline have been switched at the end of the B chain of the insulin molecule.
Cost
In the United States, in 2015, the cost was between and per 100 units. In April 2019, Eli Lilly and Company announced they would produce a version selling for per vial, about half the then current cost. The chief executive said that this was a contribution "to fix the problem of high out-of-pocket costs for Americans living with chronic conditions", but Patients for Affordable Drugs Now said this was just a public relations move, as "other countries pay for a vial of insulin." The cost in the United Kingdom was between and per 100 units, in 2017.
History
Insulin lispro was granted marketing authorization in the European Union in April 1996, and it was approved for use in the United States in June 1996. Insulin lispro was granted marketing authorization in the European Union in May 1997, and again in August 2001. Combination drugs combining insulin lispro and other forms of insulin were approved for use in the United States in December 1999. Insulin lispro Sanofi was granted marketing authorization as a biosimilar in the European Union in July 2017. Insulin lispro injection was approved for use in the United States in December 2017. In January 2020, the Committee for Medicinal Products for Human Use in the European Union recommended granting of a marketing authorization for insulin lispro acid for the treatment of diabetes mellitus in adults. Insulin lispro was approved for use in the European Union in March 2020, and in the United States on June 18, 2020 as reported by Medscape.
