ICAM2
Intercellular adhesion molecule 2, also known as CD102, is a human gene, and the protein resulting from it.Protein structure
The protein encoded by this gene is a member of the intercellular adhesion molecule family. All ICAM proteins are type I transmembrane glycoproteins, contain 2–9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein.ICAM-2 molecules regulate spermatid adhesion on Sertoli cell on the apical side of the blood-testis barrier, thus playing a major role in spermatogenesis.
This protein may also play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.Interactions
ICAM2 has been shown to interact with EZR.
