Hypoxia-inducible factor-proline dioxygenase
Hypoxia-inducible factor-proline dioxygenase is an enzyme with systematic name hypoxia-inducible factor-L-proline, 2-oxoglutarate:oxygen oxidoreductase . This enzyme catalyses the following chemical reaction
Hypoxia-inducible factor-proline dioxygenase contains iron, and requires ascorbate.
In humans, there are three isoforms of hypoxia-inducible factor-proline dioxygenase. These are PHD1, PHD2 and PHD3. PHD2, in particular, was identified as the most important human oxygen sensors due to its slow reaction with oxygen.
