The series follows the adventures of Christopher Chance, a Vietnam War vet turned bodyguard and private investigator who uses advanced technology and sophisticated makeup to assume the identity of his client, becoming a human target. In a departure from the original comic book stories, Chance flies from job to job in a large, gizmo-laden stealth aircraft known as the Blackwing. Additionally, he is assisted by computer expert Philo Marsden, Blackwing pilot Jeff Carlyle, and former CIA operative Libby Page. Page coordinated Chance's missions, Carlyle also served as cook and chauffeur, while Marsden created new gadgets and developed the masks Chance used to impersonate his clients. Chance took an unusual approach to compensation for his services: ten percent of his client's annual income. One reviewer described the show as "50 percent and 50 percent Quantum Leap."
The show was created by Warner Bros. Television and Pet Fly Productions, producers of The Flash and later The Sentinel for Paramount Pictures. The original pilot for the series was in filmed in 1990 but ABC declined to pick up the series for the 1990-91 television season and this pilot never aired. In the original unaired pilot, musician Clarence Clemons who was trying to establish himself as an actor, played Chance's pilot and Frances Fisher as Libby Page. Harvey Shephard, then the president of Warner Bros. Television, told The New York Times in December 1991 that Human Target was intended for both American audiences and the international television market, saying "Hopefully, it's a formula for all tastes that could have a strong foreign market." The show was finally picked up in October 1991 by ABC as a seven-episode midseason replacement series, eventually airing in July and August 1992 to low ratings and poor critical reception. The debut episode aired on Monday, July 20, 1992, before moving to its regular Saturday night time slot for the following six episodes. The seventh and final episode aired on Saturday, August 29, 1992.
of Entertainment Weekly graded the series a "C−", describing the plot of the aired pilot episode as "paper-thin" and that the series as a whole "seems campy in a dumb way, with stilted dialogue and stiff action scenes". Writing in the Chicago Tribune, Rick Kogan called the series "one of the goofiest action-adventure shows you'll ever see". Terry Kelleher's review in Newsday complained that "the strangest aspect is that the actor playing 's client winds up grabbing more screen time than Springfield". Syndicated columnist Jon Burlingame of United Features credited the show with "some interesting effects" but called the drama itself "pretty tired", lamenting that "the outrageously appropriate comic-book style of The Flash" was "completely absent". Lon Grahnke of the Chicago Sun-Times found "part-time pop singer and matinee idol" Springfield "hard to believe in the title role" as a retired Special Forces commando.
