Grant was born in Augusta, Georgia. He and his twin brother, Harvey, grew up in Mitchell, Georgia and attended school in Sparta, Georgia. After he graduated from high school, he attended Clemson University, where he was a member of Pi Kappa Alpha. With Clemson, he became the first player in ACC history to lead the league in scoring, rebounding and field goal shooting. In 1987, Grant was named ACC Player of the Year, the first Clemson player to receive that honor.
NBA career
Chicago Bulls
He was drafted by the Chicago Bulls with the 10th overall pick of the 1987 NBA draft. The 6 ft 10 in tall power forward/center immediately teamed with fellow draft-day acquisition Scottie Pippen to form the Bulls' forward tandem of the future, although he initially backed up incumbent Charles Oakley, one of the league's premier rebounders and post defenders. In 1988, Grant moved into the starting lineup when Oakley was traded to the New York Knicks for centerBill Cartwright. He immediately became the Bulls' main rebounder, and established himself as the Bulls' third scoring option after Michael Jordan and Pippen, forming one of the league's best trios. Grant was noted for his defensive play; he was selected four times for the NBA All-Defensive Team. He helped Chicago win three consecutive NBA championships, securing the third with a last-second block on Kevin Johnson. Grant, who was diagnosed with nearsightedness and wore eyeglasses, began wearing goggles fitted with prescription lenses on the court starting with the 1990-91 season. The goggles soon became a trademark for Grant. Although he eventually received LASIK surgery to correct his sight, he continued to wear the goggles on the court after he had heard from parents that he had become an inspirational figure to children who wore eyeglasses. After Jordan's first retirement following the 1992–93 season, Grant became the number-two star behind Pippen, and helped the Bulls push the Knicks to seven games in the second-round playoff series before being eliminated. Grant played in the 1994 NBA All-Star Game, posting four points and eight rebounds in 17 minutes. During the 1993–94 season he recorded career-best averages in scoring, rebounding, and assists.
Grant left the Bulls as a free agent and joined the Orlando Magic, led by Shaquille O'Neal and Penny Hardaway. On May 5, 1995, Grant made the final basket in Boston Garden history in Orlando's series-clinching victory over the Boston Celtics. Grant helped the Magic reach the 1995 NBA Finals, where they were swept in four games by the Houston Rockets. Grant spent the next several seasons with the Magic.
After one year with the Sonics, he was involved in a three-way trade in which Glen Rice of the Los Angeles Lakers was sent to New York, Patrick Ewing of the Knicks was sent to Seattle, and Grant to the defending champion Lakers, reuniting him with Shaquille O'Neal and former Bulls coach Phil Jackson. He helped them win another championship in the 2000–01 season.
Return to the Magic
In the offseason, Grant decided to leave Los Angeles and sign back with the Orlando Magic. The Los Angeles Lakers would go on to win the 2002 NBA championship without Grant. Grant was ultimately cut by the Magic in December 2002 after then-coach Doc Rivers said Grant had tried to undermine the coach and was a "cancer" on the team.
Return to the Lakers
Grant chose to retire after getting cut by the Magic. However, he decided to return for another run with the Lakers for the 2003–04 season as a backup to Karl Malone. He then retired permanently following the Lakers' loss to the Detroit Pistons in the 2004 NBA Finals.