Heteroreceptor

Examples

• Norepinephrine can influence the release of acetylcholine from parasympathetic neurons by acting on α2 adrenergic heteroreceptors.
• Acetylcholine can influence the release of norepinephrine from sympathetic neurons by acting on muscarinic-2 and muscarinic-4 heteroreceptors.
• CB1 negatively modulates the release of GABA and glutamate, playing a crucial role in maintaining a homeostasis between excitatory and inhibitory transmission.
• Glutamate released from an excitatory neuron escapes from the synaptic cleft and preferentially affects mGluR III receptors on the presynaptic terminals of interneurons. Glutamate spillover leads to inhibition of GABA release, modulating GABAergic transmission.