Hesperetin
Hesperetin is the 4'-methoxy derivative of eriodictyol, a flavanone. Hesperetin's 7-O-glycoside, hesperidin, is a naturally occurring flavanon-glycoside, the main flavonoid in lemons and sweet oranges. Hesperetin are not found to a significant extent in Citrus spp.Glycosides
A variety of glycosides of hesperetin are known, including:
is an enzyme that uses hesperidin and H2O to produce hesperetin and rutinose. It is found in the hyphomycetes species Stilbella fimetaria.Effects
Hesperetin was found to be affecting the slow inactivation phase of inward sodium current channels and therefore could be used as a template to develop drugs against lethal cardiac arrhythmias in LQT3.
