HORMAD1


HORMA domain-containing protein 1 also known as cancer/testis antigen 46 is a protein that in humans is encoded by the HORMAD1 gene.

Function

HORMAD1 plays a key role in meiotic progression. Regulates 3 different functions during meiosis. It:
  1. ensures that sufficient numbers of processed DNA double-strand breaks are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends.
  2. promotes synaptonemal-complex formation independently of its role in homology search.
  3. plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin and meiotic prophase quality control in both sexes