She saw little action early in her life, due to the end of the Napoleonic Wars. However, in the journal of Thomas Reed Stavers, she is recorded as being at Callao Roads, under Captain Thomas Maling, on 3 July and on 4/5 September 1824, on the latter occasion sailing from Callao to 'the Island of Lorenzo' to avoid attacks by a Spanish gun boat. Letters in the Foreign Office and a detailed record in the Reverend Slavin diary written while he was on board, show that the Cambridge sailed to the Americas under Captain Thomas Maling. She left Portsmouth on 5 January 1824 with 72 passenger including the new British Consuls to Peru – Thomas Rowcroft, Chile – Christopher Nugent, Argentina – Woodbine Parish and Uruguay – Thomas Samuel Hood. Vice consuls included Udney Passmore, John White, Henry William Rouse, Matthew Carter, Charles Griffiths and Richard Franklin Pousett. The ship sailed to skirted just west of Portuguese Madeira and anchored at Santa Cruz in Teneriffe. She then sailed past Cape Verde and sighted the South American continent near Cape Frio on 21 February 1824. She the sailed into Rio de Janeiro where a refit took place. The ship left on 12 March for Monte Video, where Consul Hood and his party disembarked. Rowcroft and parish with their parties took the English Packet up to Buenos Ayres where Woodbine was to be stationed. Thomas Rowcroft rode his horse right across the continent and over the Andes mountains to Valparaiso. Meanwhile, the Cambridge sailed from Monte Video around Cape Horn and up the western coast of South America to drop Consul Hood and family at Valparaiso on 26 March 1824 and pick up Rowcroft. The ship then sailed on 27 May further north to Callao Harbour and Rowcroft and his daughter, Leonora Maria, disembarked there for his post at Lima. Rowcroft was accidentally shot by Simon Bolivar's men on the evening of 6 December 1824 and died the next day. Captain Maling buried him on San Lorenzo Island. By January 1830 she was out of commission at Sheerness, but on 31 January that year she was commissioned there under Captain Edward Barnard and from then until 26 January 1843 served as the head of a naval squadron in the Mediterranean. This squadron's actions included operations in the eastern Mediterranean on the coast of Syria, a bombardment of Beirut on 10 September, and blockading Alexandria, all as part of the 1840 combined Ottoman-British campaign against Mehmet Ali.
Fate
On her return, she was again decommissioned and in ordinary at Devonport, until on 9 August 1856 when she was recommissioned as 'the gunnery ship at Plymouth', under Captain Richard Strode Hewlett. In this role she saw four more captains before being scrapped in 1869. HMS Windsor Castle was renamed HMS Cambridge and replaced her as the gunnery ship.
