HLA-C
HLA-C belongs to the MHC class I heavy chain receptors. The C receptor is a heterodimer consisting of a HLA-C mature gene product and β2-microglobulin. The mature C chain is anchored in the membrane. MHC Class I molecules, like HLA-C, are expressed in nearly all cells, and present small peptides to the immune system which surveys for non-self peptides.
HLA-C is a locus on chromosome 6, which encodes for many HLA-C alleles that are Class-I MHC receptors. HLA-C, localized proximal to the HLA-B locus, is located on the distal end of the HLA region. Most HLA-C:B haplotypes are in strong linkage disequilibrium and many are as ancient as the human species itself.Disease associations
Cw1: multinodular goitersC*16: B chronic lymphocytic leukemiaNomenclature
C*01
- Cw1 serotype: C*01:02 and C*01:09
- Cw11
- C*01:04 to *01:08
C*02
- Cw2 serotype: C*02:02 and *02:08
- C*02:03 to *02:07, and 02:09
C*03
- Cw9 serotype: C*03:03
- Cw10 serotype: C*03:02, *03:04, and *03:06
- Cw3 serotype: C*03:07
- C*03:05 and 03:08
C*04
- Cw4 serotype: C*0401, *0407, and *0410
C*05
- Cw5 serotype: C*05:01 and *05:02
- C*05:03 to *05:06 and *05:08 to *05:10
C*06
- Cw6 serotype: C*06:02 and *06:05
- C*06:03, *06:04 and *06:06 to *06:11
- Cw7 serotype: C*07:01 to *07:06, *07:12, *07:14, *07:16
- C*07:07 to *07:11, *07:13, *07:15, and *07:17 to *07:29
C*08
- Cw8 serotype: C*08:01, *08:02 and *08:03
- C*08:05 to *08:12
Others
- C*12:02 to *12:15
- C*14:02 to *14:05
- C*15:01 to *15:11
- C*16:01 to *16:06
- C*17:01 to *17:03
- C*18:01 and *18:02
Cw4-B35
Cw7-B7
Cw7-B8
Cw1-B46
Cw5-B44Interactions
HLA-C has been shown to interact with:
