Greene St. began in the early 1970s as the 112 Greene St. Recording Studio. It was originally a private recording studio for the original two owners, Jeffrey Lew and Michael Reisman and their friends. It was not a commercial venture. In the summer of 1975 the owners realized that the cost of running the studio for themselves and their friends was not cost sustainable. Jeffrey Lew turned to his and Phillip Glass’s friend, Peter McKenzie, whose family Bob Dylan had lived with in 1961 when Mr. McKenzie was 15, to manage the recording studio and bring in outside commercial business so the studio could financially support itself. This Mr. McKenzie did using his social skills and connections to bring in outside recording artists such as Asford and Simpson and the studio began to generate a nice profit allowing it to remain viable. Later in 1975 Jeffrey Lew wanted to divest his share and go on to other ventures. His share was sold to two clients Mr. MCKenzie had brought in, Billy Arnell and Steve Loeb. The transition was not smooth. It had been agreed that should any client Mr. McKenzie bring in decide to buy out a share of the studio he would be paid 10% of the purchase price. After the sale was completed Mr. McKenzie was denied his fee. A lawsuit followed. Mr. McKenzie was paid and ways were parted. The studio having been elevated to a profit sustainable enterprise at the time of the sale and settlement of the lawsuit. was renamed “Big Apple Recording'''. It then became a partnership between Michael Riesman and producer Steve Loeb. The new studio manager was Jonathan Katz who would later make a name for himself as "Dr Katz" a popular albeit cartoon figure on Comedy Central and the first studio chief engineer was Wieslaw Woszczyk now Dr. Wieslaw Woszczyk who holds the James McGill Chair Professorship in Sound Recording and is the Founding Director of the Centre for Interdisciplinary Research in Music Media and Technology at McGill University. In 1983 Loeb bought out Riesman and became the sole owner of the studio which was renamed Greene St. Recording. Former Woszczyk assistant Rod Hui became chief engineer and Robyn Sansone became studio manager. In the first year as Greene St. under Loeb, Hui and Sansone, Greene Street recorded and mixed a number of records including the three groundbreaking hits Shannon's "Let The Music Play", Kurtis Blow's "The Breaks" and Run DMC's "It's Like That". In 1983 Dave Harrington commenced as studio manager. The studio's engineering team included Rod Hui, Nick Sansano, Jamey Staub, Andrew Spigelman, Chris Shaw, Phil Painson, Prince Strickland, Charlie Dos Santos, Chris Champion, Djini Brown, and Danny Madorsky. In 1986 Greene St. underwent renovation and an additional two rooms were added to the studio, in which the studio owners installed audio technology that was new to New York at the time. In August 24, 2014, Chuck D, of U.S. hip hop groupPublic Enemy, posted a photo on his Twitter profile of a cassette tape from the Greene St. studio. The tape's label is branded with the studio's branding and a hand-written title indicates that the studio was used for the recording of the song "Fight The Power."
Soon after the closure of Greene St. Recording, owner Steve Loeb, along with record producer artist John Robie, launched The Combine at 112 Greene Street. The new space presented a multimedia urban art project entitled "Work To Do" that featured 52 urban/graffiti artists. In 2011 the space was rejoined with the upper floor, reforming its original configuration, and leased to fashion designer Stella McCartney, daughter of Beatles bassist Sir Paul McCartney. A December 2011 media article showed that Stella McCartney continued to use the 5,200-square-foot space for her flagship retail outlet at that time.