The original Hellenistic colonnade was devastated, along with the rest of Apamea, in the 115 earthquake. Reconstruction started immediately under the Romans, and over the course of the second century the city was completely rebuilt, starting with the Great Colonnade. The colonnade was aligned along the north-south axis, making up the city's cardo maximus under the Romans. Starting at the city's north gate, the colonnade ran in an uninterrupted straight line for almost to the south gate. The northern third of the colonnade's stretch is marked by a monumental votive column that stood opposite the baths. The southern third, at around, is marked by the intersection with the city's main east-west axis, or the decumanus maximus. Two triple arches were built into the Great Colonnade as part of the intersection. The colonnade was further intersected by side streets at regular intervals of. The colonnade passed through the center of the city and several important buildings were clustered around it, including the baths, the agora, the Temple of Tyche, the nymphaeum, the rotunda, the atrium church and the basilica. The street within the colonnade was wide and paved with large polygonal limestone blocks. On either side of the street a wide colonnade ran its full length. The columns were high and in diameter. They stood on square bases of on a side and high. The columns display two main designs: a plain one, and the distinctive spiral-flutes. Archaeologist Jean Lassus argues that the former dates back to the Trajanic period, while the latter to that of Antoninus Pius. The colonnade's porticoes were paved with extensive mosaics along the full stretch of the colonnade. Under the Byzantine Emperor, Justinian I, several parts of the colonnade were restored. The street was narrowed to by adding a sidewalk on either side. Several stretches of the street had their Roman pavement replaced with a new pavement made of squared blocks of limestone. The new pavement also covered a completely overhauled drainage system. Justinian's changes included erecting a monumental tetrastylon made up of four high columns with a meter-high capitals. The city, was however, later sacked by the Sasanians under Adarmahan.
