Her teaching career started at Queen's School, Ede Osun State, where she was mathematics teacher from 1954 until 1957. She left for the University of Vermont to become a graduate assistant and later assistant professor. Between 1963 and '65, Alele-Williams was a postdoctoral research fellow, department of Education, University of Ibadan from where she was appointed a professor of mathematics at the University of Lagos in 1976. She was the first female Vice Chancellor in Nigeria. She has held and served in various capacities. By serving in various committees and boards, Alele-Williams had made useful contributions in the development of education in Nigeria. She was chairman of the curriculum review committee, former Bendel State 1973–1979. From 1979 to 1985, she served as chairman of the Lagos State Curriculum Review Committee and Lagos State Examinations Boards. Alele-Williams was a member of governing council, UNESCOInstitute of Education. She is also a consultant to the United Nations Educational, Scientific and Cultural Organization and Institute of International Education Planning. For a decade she was a member of the African Mathematics Programme, located in Newton, Massachusetts, United States. She was also vice-president of the World Organisation for Early Childhood Education and later president of the Nigeria chapter. Alele-Williams has published a book titled Modern Mathematics Handbook for Teachers. After serving as the Vice-Chancellor of the University of Benin, she joined the board of directors of Chevron-Texaco Nigeria. She is also on the board of HIP Asset Management Company Ltd, an Asset Management Company in Lagos, Nigeria. Professor Grace Awani Alele-Williams was a force to reckon with in the dark period for Nigeria's higher education. Then, the activities of secret cults, confraternities and societies had spread within the Nigerian Universities especially in University of Benin. She made valuable impacts, with combination of courage, ingenuity and strategy that the growing tide of cultism was stemmed in the university. A task which many men had failed, she was able to make notable contributions. She has a special interest in women education. While spending a decade directing the Institute of Education, she introduced innovative non degree programmes, allowing older women working as elementary school teachers to receive certificates. Alele-Williams has always demonstrated concern for the access of female African students to scientific and technological subjects.
Publications
Dynamics of Curriculum Change in Mathematics - Lagos State Modern Mathematics Project.