Ghassan Salamé taught international relations at the American University of Beirut and Saint Joseph University in Beirut and, later, at the University of Paris. In 2000–2003, Salamé was Lebanon’s Minister of Culture, as well as Chairman and Spokesman of the Organization Committee for the Arab Summit and of the Francophone Summit in Beirut. Salamé presently sits on the board of the International Crisis Group, the International Peace Institute, the Open Society Foundations, the Bibliotheca Alexandrina, and several other non-profit organizations. He was also the senior advisor to the United Nations Secretary-General from 2003 to 2006 and again in 2012. He was the political advisor to the United Nations Assistance Mission for Iraq in 2003, where he played a critical role in bringing together Iraqi factions. He is the chairman of the Arab Fund for Arts and Culture. Salamé also sat on the Board of the Centre for Humanitarian Dialogue from 2011 to 2015. In 2016, he joined the Commission on the Rakhine State, which was chaired by former UN Secretary General Kofi Annan. Salame is a Member of the Global Leadership Foundation that works to support democratic leadership, prevent and resolve conflict through mediation and promote good governance in the form of democratic institutions, open markets, human rights and the rule of law. On 22 June 2017, Salamé was appointed Head of the United Nations Support Mission in Libya, replacing Martin Kobler. On 5 August 2017, he made his first official visit to Libya after assuming the role of the head of United Nations Support Mission in Libya by arriving at Mitiga Airport in Tripoli. During 2018–2019, he mediated between political and social groups in Libya, with the aim of holding a meeting in Ghadames called the Libyan National Conference, for organising elections and to revive the Libyan peace process. In February 2020, he eventually brought delegations from the two main sides in Libya’s conflict to Geneva for peace talks, but key representatives suspended their involvement. Shortly after, shelling in Tripoli had again intensified into some of the heaviest bombardments since Salame brokered a ceasefire earlier that year. On 2 March 2020, Salamé resigned as the head of the United Nations Support Mission in Libya citing stress and health concerns. In a statement on Twitter, he said he had been frustrated with foreign powers, particularly France and Russia for covertly backing Khalifa Haftar's forces in the civil war.