Houston's Broadway credits included The O'Flynn, Caviar, Shooting Star, Melody, A Modern Virgin, The Venetian Glass Nephew, Fioretta, and Chee-Chee. After doing some stage acting on Broadway, Houston was enticed to try his acting skills in Hollywood by the early 1930s, hoping to win parts in singing films. He received small bit parts in six different films, but no roles that cast him in a starring role. After his sixth, he found himself unemployed. On September 8, 1933 in New York City, Houston married Leone Sousa, a model and Ziegfeld girl. They later moved to Los Angeles, California. In 1936, Houston and Sousa performed together in the play Everyman, produced by the California Festival Association at the Hollywood Bowl. In 1935, Houston was noticed by small production company Grand National Pictures, who hired him to play the lead role in a series of musical westerns including the 1936 film Captain Calamity and the 1938 filmFrontier Scout. The 1938 film was successful and brought Houston to the notice of other production companies. That same year he would play a small role in Blockade with Henry Fonda and Madeleine Carroll, in which he was billed as "George Byron". In MGM's movie The Great Waltz, also released in 1938, he played the opera singer Fritz Schiller. On February 21, 1940, Houston and Sousa divorced, after having parted on November 1, 1939. Sousa spoke about Houston in court: "He paid practically no attention to me. He'd go out socially without me and he wouldn't return until some time between 2 and 5 o'clock in the morning. He was always having bills for champagne sent to our home. But I never saw the champagne." Sousa was awarded the divorce decree and Houston was made to pay her $200 a month in alimony until one of them died or Sousa remarried. Houston later married opera singer Virginia Card, who he stayed with until his death. By 1940, following several failed film endeavors, Grand National Pictures was in trouble, and they went out of business soon after. Houston had been billed prior to this time by a new company, Producers Releasing Corporation, as the future character of Billy the Kid in an eight film series for that company. However, when it came time to film the series, Bob Steele was cast in the role for six episodes, and was replaced by Buster Crabbe following Steele's departure to Republic Pictures. Despite his not being cast in the "Billy the Kid" role, PRC gave Houston his own series of films. He would make eleven films as "The Lone Rider", beginning with the 1941 film The Lone Rider Rides On, in which he sang the theme song in an equally rousing tenor voiceat the beginning and end. Al "Fuzzy" St. John played his sidekick in all eleven films. However, by the end of 1942, Houston was replaced by veteran actor Bob Livingston as the "Lone Rider." St. John and actor Dennis Moore would remain with the series. Houston planned to return to his singing interests, but died unexpectedly on November 12, 1944. After a rehearsal of a film, Houston had a few drinks and collapsed from a heart attack. The police, thinking he was drunk, deposited him in the drunk tank. He then died either in the drunk tank or on the way to hospital. His wife, Virginia Card, was at the time starring in the Broadway hit Oklahoma!, which had just debuted in 1943. Houston was, at the time of his death, preparing to take his opera company on a nationwide tour. George Houston was beloved as a voice teacher and coach by Howard Keel and John Raitt. Keel wrote in his autobiography Only Make Believe that Houston was "...like a father to me.", and described his death.
