Harrison was born in May 1915 in Shammer, Kilkelly, County Mayo, Ireland to parents Tom ‘Yank’ Harrison and Winnie McDermott. The Shammer Harrison grew up in has been described as fiercely Irish Republican, and it was there that the young Harrison experienced the chaotic years of both the Irish War of Independence and the Irish Civil War. In one incident that stayed with him for the rest of his life, he remembered a visit by the Black and Tans to his mother's shop that ended with them assaulting him. During the Civil War a cousin of Harrison, Michael Duffy, was shot while fighting as a part of the Anti-Treaty IRA. Both these incidents contributed to his growing belief inIrish Republicanism. At age 16 in 1931 Harrison joined what remnants remained of the Irish Republican Army. However, by this point, the IRA was at a low ebb and his unit never saw any actual fighting. By the mid-1930s he had emigrated to England where he worked as a farm labourer. He briefly returned to Ireland in 1938 before emigrating again, this time to the United States, settling in New York City. Between April 1944 and February 1946 he served with the US Army in World War II in the Pacific Theatre. Following the war he became active in Irish-Americanpolitical organisations such as Clan na Gael and the James Connolly Club. It was during this time Harrison became affiliated with Liam Cotter, a fellow Irish immigrant from County Kerry who had also spent time in the IRA. At some point in the mid-1950s, the IRA approached Cotter and Harrison about supplying them arms for their Border Campaign, a request which the pair accepted, beginning a gun running career which would last for several decades. Harrison was able to source arms for the IRA through George de Mao, an Italian-American neighbour of his who had connections to the Mafia as well as gun runners who were supplying rebels in Cuba. In 1962 Cotter and Harrison cut their ties with the IRA as it became apparent the Border campaign was a failure. However, in 1970 Dáithí Ó Conaill was able to convince them to support the Provisional IRA and they once again began supplying arms to Ireland. In 1975 Harrison appeared before a grand jury investigating arms trafficking; however, he was released without charge.
In 1981, Harrison was arrested in an FBI sting code-named "Operation Bushmill". Harrison, Tom Falvey, Michael Flannery, Pat Mullin, and Danny Gormley were acquitted in a criminal trial held in New York City, which lasted from December 1980 to June 1981. Their acquittal was widely attributed to the unconventional efforts of Harrison's personal attorney, Frank Durkan; the men admitted to their activities but claimed that they believed the operation had Central Intelligence Agency sanction. During the trial, a number of people spoke on the defendants' behalf, including Bernadette Devlin.
Post-acquittal
Although he had spent much of the previous decade involved in this operation, his acquittal marked the end of his active career as an IRA gun-runner. Throughout his life he would devote his time to other various left-wing causes, including support for the African National Congress, the Sandinista movement, the Cuban Revolution, the Second Spanish Republic during the Spanish Civil War and the Independista campaign against Puerto Rico's status as an American Commonwealth. Harrison broke with the Provisional Republican Movement in 1986 when Provisional Sinn Féin dropped the traditional Republican stance of not taking their seats in the Irish parliament. He remained within the Republican Movement through Republican Sinn Féin and was a founder and activist of the Republican support group Cumann na Saoirse/Irish Freedom Committee in the US. He was a patron of Republican Sinn Féin until he died. He also took a number of controversial stances within the broader Irish-American community within New York City, including outspoken support for former Mayor David Dinkins, support for the inclusion of LGBT marchers in the New York Saint Patrick's Day Parade and his open defiance of the Ancient Order of Hibernians. He died at the age of 89 in October 2004 from natural causes at his home in Brooklyn, New York City.