GURPS Wild Cards is a supplement and campaign setting for use with GURPS Supers, set in the milieu of the Wild Cards science-fiction shared-world series, a world in which an alien virus has given certain humans incredible powers. Data and characters are drawn from Wild Cards volumes I-V, including a history of the Wild Cards world, the Wild Card virus, over 50 super-characters, variant historical characters, a description of Jokertown, the major Wild Card organizations, and the various aliens. The book also includes guidelines on how to run a Wild Cards game, plus a glossary of Joker and Takisian terms.
reviewed GURPS Wild Cards for Dragon magazine #178. He declared: "Recommended to super-hero fans in general and GURPS Supers game enthusiasts in particular, this exceptional supplement discusses the world of the Takisian wild card virus in fascinating detail, addressing many of the questions left unanswered in the Bantam Spectranovel series, such as exactly how the virus triggers human mutations, the history of the Shadow Fist Society, and the mysterious link between the Wild Cards phenomena and baseball. Game statistics and background dossiers are given for the Great and Powerful Turtle, Sewer Jack, and dozens of other memorable characters, along with useful suggestions for creating player-designed mutants. The section discussing actual role-playing is disappointingly skimpy. GMs are pretty much on their own when it comes to creating adventures, and the artwork is adequate at best. Otherwise, this is a terrific effort. Be forewarned that, like the novels, this supplement is not intended for children." John Sullivan reviewed GURPS Wild Cards in Space Gamer/Fantasy Gamer #88. Sullivan commented at the end of his review: "GURPS Wild Cards successfully addresses ways to run a successful Supers campaign using the world of the Wild Cards. The world flavor is highly described and guidelines for adventures and play are given. For those of you who have been waiting to play in this world, now you can. However, this addresses one other problem with this worldbook; you need TWO other Steve Jackson Games products to play it, GURPS Basic and Supers. This is going to cause some players to take a hard look at Wild Cards; do they want to buy a GURPS worldbook to play a GURPS worldbook? If they want to play Wild Cards, then the answer is a resounding yes! If they are going to be using it as a separate world or a sourcebook for characters only, then the price is a little steep ; they would be better off to buy a villains book and an adventure supplement." GURPS Wild Cards was also reviewed in Games Review Vol. 2 #4 Game designer Shannon Appelcline considered GURPS Wild Cards an "ironic property" since it was a GURPS book based on a series of novels that were originally based on a roleplaying campaign that had been run using Chaosium's Superworld system.