GSK3A
Glycogen synthase kinase-3 alpha is an enzyme that in humans is encoded by the GSK3A gene.
Glycogen synthase kinase 3-alpha is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' and implicated in the control of several regulatory proteins including glycogen synthase and various transcription factors. It also plays a role in the WNT and phosphoinositide 3-kinase signaling pathways.Model organisms
s have been used in the study of GSK3A function. A conditional knockout mouse line, called Gsk3atm1aWtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty one tests were carried out on mutant mice but no significant abnormalities were observed.
