GABBR1
Gamma-aminobutyric acid B receptor, 1, is a G-protein coupled receptor subunit encoded by the GABBR1 gene.Function
Gamma-aminobutyric acid is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic receptors, to produce fast synaptic inhibition, and metabotropic receptors, to produce slow, prolonged inhibitory signals. The GABA receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA receptor 1 and GABA receptor 2. The GABA receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.Interactions
GABBR1 has been shown to interact with ATF4 and GABBR2.
