Francis was born on 23 November 1508 in Uelzen. His father, Henry the Middle, had planned that Francis would later become the Bishop of Hildesheim, but that proved impossible due to the worsened political situation. After his father was exiled to Paris in 1521, his two elder brothers, Otto and Ernest the Confessor, ruled the severely indebted Duchy of Celle. They arranged for their brother, Francis, who was too young to share power, to have a professional education and, at the age of 16, sent him to the University of Wittenberg. When he came of age in 1526, he spent another ten years at the court of the Electorate of Saxony. There he was impressed by the extravagant courtly life at the royal court with its feasting, hunting and travelling. Not until 1536 did he return to Celle at the prompting of his elder brother, Ernest, who had since espoused the Lutheran doctrine.
On his return, Francis showed no interest in the royal responsibilities expected of him. Moreover, the relatively modest standard of living in the little Residenz at Celle was not to his liking. By way of settlement he insisted on his own dukedom and pressed for a division of the territory. His demand for the whole eastern half of the duchy was unacceptable, not least due to the serious debts owed by the state. As a result, in 1539 he was only given the Ämter of Gifhorn, Fallersleben and Isenhagen Abbey near Hankensbüttel. These estates eventually made up the new Duchy of Gifhorn, a state of only of minor importance in the empire. It was a small, easily managed lordship, in which Duke Francis could indulge his noble image of himself and attended to his princely representational duties unfettered. He had Gifhorn Castle expanded as his Residenz and led an ostentatious, courtly life. At the same time he built Fallersleben Castle as a rural aristocratic estate.
In 1547 Duke Francis married Clara of Saxe-Lauenburg, the daughter of Duke Magnus I of Saxe-Lauenburg in Ratzeburg. The marriage lasted only three years before the duke died in great pain on 23 November 1549 on his 41st birthday. The cause was an infection of his foot that did not heal and even an amputation could not save his life. He was interred in the chapel at Gifhorn Castle, where there is still a carved tomb figure on his sarcophagus. Because there were only 2 daughters from his marriage, the Duchy of Gifhorn returned to the family line in Celle. His wife, the Duchess Clara, was given Fallersleben Castle as her dowager home where she applied herself wholeheartedly to the common good of the place. She died in 1576 during a visit to Barth and was interred there.
