President of the Artistic-Cultural Commission of the Grand Jubilee Year 2000
On 24 April 2002 he was named to succeed Cardinal Virgilio Noè as Archpriest of the Patriarchal Vatican Basilica, Vicar General for the State of Vatican City, and President of the Fabric of Saint Peter. At the next consistory in 2003 he was made Cardinal-Deacon of Santa Lucia del Gonfalone. He was later named President of the Permanent Commission for the Care of the Historical and Artistic Monuments of the Holy See, serving from 8 March 2003 to 3 July 2009. He passed the normal retirement age of 75 for Curial positions in 2004, though this is frequently waived. After the death of Cardinal Jan Pieter Schotte, Cardinal Marchisano was named on 5 February 2005 to succeed him as President of the Labour Office of the Apostolic See, retaining his other positions, while Archbishop Angelo Comastri was named to the unusual position of Coadjutor Archpriest of Saint Peter's and as Marchisano's successor Vicar General for the State of Vatican City, and President of the Fabric of Saint Peter. Cardinal Marchisano was one of the cardinal electors who participated in the 2005 papal conclave that selected Pope Benedict XVI. In a funeral Mass for Pope John Paul II celebrated the day after his funeral, Cardinal Marchisano revealed that he had been cured of an illness of the throat after the late pope had prayed and touched him. On 31 October 2006, Pope Benedict named Angelo Comastri to succeed Cardinal Marchisano as Archpriest of St Peter's Basilica. On 3 July 2009, Marchisano resigned as president of the Labour Office of the Apostolic See and as president of the Permanent Commission for the Custody of Historical and Artistic Monuments of the Holy See. Following the conclave that elected Pope Francis, Marchisano was one of the six cardinals who made the public act of obedience to the new pope on behalf of the College of Cardinals at the papal inauguration ceremony. Having served 10 years as a cardinal-deacon, he was promoted to cardinal-priest by Pope Francis on 12 June 2014. Marchisano died in Rome on 27 July 2014 at the age of 85. At the 28 June 2018 consistory, Pope Francis assigned the diaconate church of Santa Lucia del Gonfalone which Marchisano previously lead to Aquilino Bocos Merino.