Born in Monaco, Bosio was given a scholarship by prince Honoré I to study in Paris with the eminent sculptor Augustin Pajou. After brief service in the Revolutionary army he lived in Florence, Rome and Naples, providing sculpture for churches under the French hegemony in Italy in the 1790s. He was recruited by Dominique Vivant Denon in 1808 to make bas-reliefs for the monumental column in the Place Vendôme in Paris and also to serve as portrait sculptor to Emperor Napoleon I and his family. It was in this capacity that he produced some of his finest work, notably marble portrait busts of the Empress Josephine, which was also modelled in biscuitSèvres porcelain, and of Queen Hortense, which was also cast in bronze by Ravrio. Louis XVIII made Bosio a Knight of the Order of Saint Michael in 1821 and appointed him premier sculpteur du Roi. In 1828, Bosio saw his grandiose equestrian sculpture of Louis XIV erected in the Place des Victoires in Paris and was made an Officier of the Légion d'honneur. He was made a baron by Charles X of France in 1825. Though under Louis-Philippe he was stripped of his titles, he continued to receive official commissions, as the ablest portrait sculptor in Paris, and created the statue of Napoleon for the Column of the Grande Armée in 1840 under Napoleon III. He died in Paris. Apart from the imperial busts and the statue of Louis XVI, other important works included the quadriga of the Arc de Triomphe du Carrousel and the statue of Hercules fighting Acheloos transformed into a snake in the Louvre. Many of his most important sculptures and statues can today be found in the Louvre museum in Paris. A study of Bosio was published by L. Barbarin, Etude sur Bosio, sa vie et son oeuvre 1910.
* Aristaeus, god of gardens, An official commission for the Imperial palaces through Vivant-Denon, 7 December 1812; marble delivered to Bosio January 1813.
* Henry IV as a child This was commissioned for his study at the Tuileries by Louis XVIII; it was cast in silver by the silversmith Charles-Nicolas Odiot
* Queen Marie-Amélie, standing figure. Bosio's original plaster, pointed for a marble version, is at the Louvre Museum at Saint-Omer. The marble, finished after Bosio's death by his nephew, is at Versailles.
Elsewhere
:File:François Joseph Bosio-Cupid with a Bow-Hermitage.jpg|Cupid with a bow
Bust of Queen Marie-Amélie of France
:File:Bosio - Portrait of the Marquis d'Aligre CLPH 54.59.JPG|Bust of the marquis d'Aligre owner of the Château de Baronville