The Famatinian orogen's main outcrops lie in Sierras Pampeanas in northwestern Argentina. Only the western part of Sierras Pampeanas bears evidence of the Famatinian orogeny; the eastern parts appear to have been largely unaffected. In northern Chile the Belén Metamorphic Complex is believed to be part of the orogen as it was subject to metamorphism in the early Paleozoic. To the south in La Pampa Province, outcrops associated with the orogeny are scarce since most of that region has become blanketed by much more recent Quaternary sediments. In Peru's Cordillera Oriental a "Famatinian" orogeny exists which is coeval with the classical Famatinian orogeny found further south. In the time-span from 480 Ma to 435 Ma rocks of Cordillera Oriental were deformed and a magmatic arc developed. Towards what is now the east of the Famatinian magmatic arc a Precambriansedimentary basin developed into a back-arc basin during the Ordovician. This basin went from Peru, through Bolivia to northwestern Argentina. The basin collected sediments from the Famatinian orogen and arc and while it did not contain oceanic crust it was a marine basin.
Famatinian arc magmatism was caused by the subduction of Iapetus Oceanlithosphere beneath Gondwana. As subduction went on, the peak of the orogeny resulted from the collision of the Cuyaniaterrane with Pampia in the Ordovician. It has been suggested that the coeval AppalachianTaconic orogeny is the "northward" continuation of the Famatinian orogeny. This has been explained by adding that the continent Laurentia could have collided with Gondwana in early Paleozoic times due to the closure of the Iapetus Ocean. Supporting this hypothesis is the suggestion that the orogens have "truncated ends" that can be matched and that both share the commonality of having carbonate platform sediments at what is today their western side. Further, in the mentioned sediments both orogens host similar Olenellid trilobite faunas, something that is not expected to be unless both orogens had some sort of contact. This is because trilobites are unable to cross deep ocean basins. According to this view the Cuyania terrane would be an allochthonous block of Laurentian origin that was left in Gondwana after the continents went apart. But such views are not unchallenged since Cuyania is alternatively suggested to have drifted across Iapetus Ocean as a microcontinent starting in Laurentia and accreting then to Gondwana. Further a third model claims Cuyania is para-autochthonous and arrived at its current place by strike-slip fault movements starting not from Laurentia but from another region of Gondwana. The fact that Precordillera terrane has many trilobite genera in common with Laurentia but many species are endemic have led to some differing interpretations on what paleogeographic and tectonic history conditions are plausible explanations for this biogeography.