Born in the city ofAlfaro, La Rioja, Spain to Félix Moreno and María Josefa Díaz, he was the third of six children along with Eustaquio, Juana, Valentina and Benigna. His fourth sister, named María de las Candelas, died. Ezequiel first wore the habit of the Recoletos in Monteagudo, Navarra, Spain on September 21, 1864. Later, he made his solemn vow in Marcialla on September 22, 1868.
The monastery in Monteagudo was known for dispatching missionaries to both the Americas and the Philippines. As expected, the saint sailed for Manila, the capital of the Captaincy General of the Philippines, arriving there on February 10, 1870. In the middle that year, St. Ezequiel sailed on to the Visayan town of Jaro, Iloilo where he received and finished his minor orders. A year later, he returned to Manila to receive his sacerdotal orders from the Archbishop of Manila, Gregorio Melitón Martínez. Today, the letter of the Archbishop informing him of his sacerdotal ordination is one of the best-preserved manuscripts from the period. After ordination, he was immediately sent to his first mission in Calapan, Oriental Mindoro. There, he became proficient in Tagalog that at his canonisation, Filipino Catholics remarked that the language is now "a language of the saints."
In 1876, he was transferred to what is now Las Piñas and worked zealously for the development of the lives of the people in the area. The town suffered many major calamities during his pastorship, yet the people did not lose hope because of his example. This saintly way of life that he exemplified caused the people of Las Piñas to oppose his transfer to Santo Tomás, Batangas. The appeal, as strong as it was, was not successful and St. Ezequiel was transferred to Santo Tomás. However, he was recalled to Manila because he was appointed General Preacher of the Order of Augustinian Recollects. The people of Santo Tomas also made an appeal to suspend the order but like what happened in Las Piñas, their request was not granted. He assumed the post in October 1880 and as Preacher General, was assigned parish priest of Santa Cruz Church, assuming the post in February 1881. A year later, he was assigned to take charge of the Recollect hacienda in the towns of Imus and Bacoor in Cavite. During his stay, the towns were struck by cholera and the priest worked hard to administer the Last Rites to as many of the faithful as possible that of the 3,200 victims, only three died without receiving the Last Rites.
Election as superior of Monteagudo
His saintly life made him elected as Superior to the Seminary in Monteagudo in 1885. Through this post, St. Ezequiel imparted his missionary zeal to many missionaries to the Americas and the Philippines.
Colombian missions
It was in 1888 that he once more crossed the Atlantic Ocean and became the head of the Recollect mission in Colombia. He served as Vicar apostolic of Casanare and was named bishop of Pinara, Colombia on October 23, 1893. He became Bishop of Pasto, Colombia on December 2, 1893. He was noted for his generous charity to the faithful of his diocese and his ardent attacks against the liberal party from the pulpit.