Chemerinsky taught for over twenty years at the University of Southern California Law School and at DePaul University College of Law before moving to Duke University on July 1, 2004, and then UC Irvine in July 2008. In July 2017, he started a five-year term as dean of the UC Berkeley School of Law. In 1995, Chemerinsky was a commentator on the O.J. Simpson trial on KCBS-TV, KNX, and CBS News. Chemerinsky has published six books, numerous articles, and a regular column on the United States Supreme Court carried by California Lawyer, the Los Angeles Daily Journal, and Trial Magazine. Chemerinsky has also argued several cases before the United States Supreme Court, including United States v. Apel, Scheidler v. NOW, Tory v. Cochran, Van Orden v. Perry and Lockyer v. Andrade. In March 2011, The National Jurist: The Magazine for Law Students named Chemerinsky one of the "23 Law Profs to Take Before You Die". Other notable work included:
Los Angeles Police Department panel reviewing the Rampart Scandal.
Los Angeles commission reviewing irregularities in city contracting.
Chemerinsky supports gun control and disagreed with the decision in District of Columbia v. Heller. He thinks that even if an individual's right to bear arms exists, the District of Columbia was justified in restricting that right because it believed that the law would lessen violence. George Will specifically mentioned and responded to Chemerinsky's argument in a column that ran four days later. Chemerinsky believes that Roe v. Wade was correctly decided. He says, "Judicial activism is the label for the decision that people don't like." He also believes that gay marriage should be legal. Chemerinsky also represents a client held at the Guantanamo Bay detention center. He supports affirmative action. In January 2017, Chemerinsky, along with other high-profile lawyers, sued President Donald Trump for refusing to "divest from his businesses".
Freedom of speech
Chemerinsky has defended freedom of speech from the heckler's veto. Following an incident in which nine members of the Muslim Students Union disrupted a speech by Israeli Ambassador Michael Oren, Chemerinsky asserted that broad freedom exists to invite speakers and hold demonstrations, but that once a speaker has begun an invited lecture, "You have the right – if you disagree with me – to go outside and perform your protest. But you don't get the right to come in when I'm talking and shout me down. Otherwise people can always silence a speaker by heckler's veto, and Babel results." After the interruptions, Oren completed his remarks and canceled the question-and-answer session. The students were arrested by University of California Irvine Police, which were on hand. However, Chemerinsky also publicly disagreed with the Orange County District Attorney's Office's decision to file criminal charges against the students.
Appointment controversy
Chemerinsky's hiring as dean of the UCI School of Law was controversial. After signing a contract on September 4, 2007, the hire was rescinded by UCI Chancellor Michael V. Drake, who felt the law professor's commentaries were "polarizing." Drake claimed the decision was his own and not the subject of any outside influence. The action was criticized by both liberal and conservative scholars, who felt it hindered the academic mission of the law school and violated principles of academic freedom, and few believed Drake's claims that it was not the result of outside influence. The issue was the subject of an editorial in The New York Times on Friday, September 14. Details emerged revealing that the university had received criticism on the hire from the California Supreme Court's Chief Justice Ronald M. George, who criticized Chemerinsky's grasp of death penalty appeals and a group of prominent local Republicans, including Los Angeles County Supervisor Michael D. Antonovich, who wanted to stop the appointment. Drake traveled over a weekend to meet with Chemerinsky in Durham, North Carolina, where he was a professor at the Duke University School of Law at the time, and the two reached an agreement late Sunday evening. On September 17, Chemerinsky issued a joint press release with Drake indicating that Chemerinsky would head the law school. The release stated that the chancellor was "commit to academic freedom." On September 20, 2007, Chemerinsky's hire was formally approved by the Regents of the University of California.