Goodpasture was born in Clarksville, Tennessee, in 1886. He received his B.A. from Vanderbilt University in 1908. In 1912, Goodpasture graduated from Johns Hopkins School of Medicine with an M.D. degree. There, under professors William H. Welch and George H. Whipple, he was subsequently appointed a Rockefeller Fellow in pathology; he held this position from 1912 to 1915. Thereafter, Goodpasture joined the faculty of Harvard Medical School, as an attending pathologist at the Penter Bent Brigham Hospital and assistant professor of pathology in Boston. During that time, Goodpasture took a two-year leave of absence to serve during World War I as a medical officer in the United States Navy. In 1919, he undertook a pathological study of the then-ongoing influenza pandemic. In doing so, he identified a patient whose infection was followed by a peculiar illness that featured hemoptysis and acute glomerulonephritis. That condition, now known as Goodpasture syndrome, is currently recognized as an immunologically mediated disease caused by autoantibodies that bind to pulmonary-alveolar, as well as glomerular-capillary, basement membranes. After leaving Harvard in 1921, Goodpasture worked at the University of the Philippines College of Medicine in Manila. From 1922 to 1924, he was the director of William H. Singer Memorial Laboratories, located in Pittsburgh, Pennsylvania. In 1924, Goodpasture was invited to return to Vanderbilt as professor and chairman of the Department of Pathology, the School of Medicine having been recently reorganized. He accepted, and held that position until 1955. Goodpasture also was the Dean of the Vanderbilt University School of Medicine from 1945 to 1950. After retirement from the latter institution in 1955, he was invited to serve as director of the Armed Forces Institute of Pathology in Washington, D.C. He did so through 1959, helping to reorganize and expand the institute's scientific mission. Goodpasture's scientific research principally concerned infectious diseases. He contributed to understanding the neural spread of herpes viruses, identification of the mumps virus, development of antiviral vaccines, and studies of rickettsial, fungal, and protozoan human diseases. In a major advance, he introduced the chicken embryo as an experimental host for investigation of microbial infections and for production of vaccines. This technique made possible the development and production of a wide range of vaccines against viral diseases. Goodpasture was a dedicated and patient teacher for medical students, graduate students, and house officers in pathology.
