Hancock spent 29 years at IBM, where she rose to senior vice president in charge of network hardware and software. She ran the networking hardware division through the first half of the 1990s, at a time when it saw double-digit losses in market share year after year. She was also a member of the IBM Corporate Executive Committee and the IBM Worldwide Management Council.
In September 1995, she was hired away from IBM by Gil Amelio to become National Semiconductor's Executive Vice President and Chief Operating Officer. She worked closely with Amelio to move National Semiconductor to profitability. During that time, Hancock worked with National's CompactRISC architecture, which was a forerunner to the successful ARM7 architecture.
Apple
Not long after that Amelio left to take the CEO position at Apple Computer, and in July 1996 he hired her to join him there. At Apple, she took over the Chief Technology Officer role in the midst of the floundering next-generation Coplandoperating system project. She was largely responsible for the decision to cancel Copland. To replace it, Hancock had favored Sun Microsystems's Solaris operating system over NeXT Inc.'s NeXTSTEP, and was against the eventual purchase of NeXT. Even after the deal was done, she wanted to use at least the kernel of Solaris. With NeXT came Steve Jobs, who publicly lampooned her on several occasions calling her a "bozo". When the Apple board of directors fired Amelio, Jobs reorganized the company leaving her with a much reduced role in charge of quality assurance as former NeXT executives took over many positions in Apple. She soon resigned.
After Apple she took a CEO position with Exodus Communications in March 1998 and became chairman of the board in 2000. Exodus set a Nasdaq record of 19 consecutive quarters of 40 percent quarter-over-quarter revenue growth. In 2000, the $29 billion market cap exceeded even that of her former employer, Apple Computer. However, in 2001 the company became part of the dot-com crash, the stock plummeted and Hancock stepped down as CEO in September 2001. The company filed for bankruptcy that same month, followed by an asset purchase by Cable & Wireless in February 2002. Savvis Communications purchased the related assets from C&W in November 2004.
Hancock served as President, COO, and secretary to the board of Acquicor, a company she co-founded with former Apple-CEO Gil Amelio and Apple co-founder Steve Wozniak. The company serves as a 'blank check' holding company. Most recently, Acquicor acquired Jazz Semiconductor. Hancock resigned on July 7, 2007.