Sanchez played baseball at San Marcos High School, excelling as a pitcher, and then continued at his career at Palomar College. However, his career was cut short when he was injured after a near fatal drunk driving accident. Sanchez was 20 years old and driving with a friend while intoxicated. Sanchez flew through the windshield and almost had one of his legs amputated because of the injuries.
On February 3, 2007, with a 1-0 promotional record, Sanchez faced Mirko Cro Cop at UFC 67. Sanchez lost via TKO due to punches at 4:33 of the first round, in Cro Cop's debut fight in the UFC. Average betting for this fight was around -1200 for Cro Cop and +800 for Eddie Sanchez, the biggest gap for underdog/favorite in UFC history. Sanchez defeated Irish heavyweight Colin Robinson by TKO at UFC 72. At UFC 79, held on December 29, 2007, Sanchez defeated Soa Palalei via TKO. Sanchez went on to lose to Antoni Hardonk at UFC 85 in London on June 7, 2008. Sanchez took the Hardonk fight on short notice, as a late replacement for Neil Wain. Sanchez was noticeably out of shape at the weigh in, but despite this, he knocked Hardonk down twice, once in the first round and once in the second, before succumbing to strikes at 4:15 in the second round. Sanchez next faced Justin McCully at on December 10,2008, he lost the via unanimous decision and was released from the promotion.
Bellator Fighting Championships
Sanchez debuted for Bellator at Bellator 7, recording a ten-second knock out. His next Bellator bout was scheduled against Ralph Kelly at Bellator 20. Kelly pulled out of the bout and was replaced by Wayne Cole. Cole then pulled out of the fight and was replaced by Marcus Sursa. Sanchez won via TKO in the third round. With this win, Eddie will take a spot in the third season heavyweight tournament.
Sanchez was scheduled to fight Bobby Lashley at Titan Fighting Championships 19. But on July 22, it was announced that Lashley withdrew from the fight due to personal reasons. Sanchez fought Strikeforce veteran Brett Rogers at Titan Fighting Championships 20. Sanchez won by split decision.
Independent promotions
Sanchez then faced Damian Grabowski at MMA Attack 2 on April 27, 2012. Sanchez was submitted via kimura at 2:02 in the second round. The following June, Sanchez faced future Bellator Heavyweight championVitaly Minakov at The Battle of Moscow 7. Sanchez was defeated in the first round via KO. After a long layoff, Sanchez eventually returned and faced Stjepan Bekavac at FFC11: Jurković vs. Kaluđerović on April 4, 2014. Sanchez was knocked out in the first round, marking his third loss in a row.