Khayat attended Moss Point High School from 1949 to 1953, where he lettered in football twice, basketball three times, and baseball three times.
College
In 1953, Khayat attended Millsaps College, where he lettered in football and basketball. In 1954, he won the Mississippi Golden Gloves Heavyweight Championship. Also in 1954, he won a scholarship to Perkinston Junior College, where he lettered in football and basketball. In 1976, he was inducted into the MGCCC Alumni Hall of Fame and in 2003 into the MGCCC Athletic Hall of Fame. In 1955, he was awarded a scholarship to Tulane University where he lettered in football twice and baseball once. He was elected to the All-Time Tulane Green Wave football team in 1979, the Tulane Green Wave football All-Century Team in 1993, and inducted into the Tulane Athletic Hall of Fame in 1981.
Professional
In 1957, he was signed as a free agent by the Washington Redskins. His playing career spanned ten years until his retirement after the 1966 season with the Boston Patriots. The bulk of his career was spent with the Philadelphia Eagles, where he was the starting defensive tackle for the 1960 World Championship team. In 2006, he was inducted into the Philadelphia Sports Hall of Fame as a member of the 1960 Eagles.
In 1991, Khayat added coaching in the Arena Football League to his résumé when he became the head coach of the New Orleans Night. In 1997, he took the helm of the Nashville Kats and led them to a 10–4 record. It was only the second time to date that an expansion team had hosted a play-off. He was honored as Arena FootballCoach of the Year for guiding the team to a division championship. He retired after the 2003 season as head coach of the Carolina Cobras.
Personal
Khayat's brother, Robert Khayat, is a former Pro Bowl kicker for the Washington Redskins. He was the recipient of the NFL's Alumni Achievement Award, the National Football Foundation Distinguished American Award, and is presently the Chancellor Emeritus of the University of Mississippi. They were one of only a few sets of brothers to play on the same team at the same time, and they are both members of the Mississippi Sports Hall of Fame. Khayat's son Bill Khayat is a former record-setting, Honorable Mention All-America tight end from Duke University, who played professionally and is a veteran collegiate and professional football coach. In 1988, Khayat continued his long association with Special Olympics when he and former Philadelphia Eagles teammate George Tarasovic co-founded a celebrity golf tournament for the benefit of York County Special Olympics. Since its inception, the tournament, which was renamed in their honor in 2015, has raised hundreds of thousands of dollars for the benefit of the county's Special Olympics programs.
Honors and awards
Mississippi Sportsman of the Year 1971, All-Time Tulane Football Team 1979, Tulane Green Wave All-Century Team 1993, Pennsylvania Chiefs of Police President's Award 1996, Arena Football League Coach of the Year 1997
Hall of Fame inductions
MGCCC Alumni Hall of Fame 1976, Tulane Athletic Hall of Fame 1981, York Area Sports Hall of Fame 1992, MGCCC Athletic Hall of Fame 2003, Mississippi Sports Hall of Fame 2004, Philadelphia Sports Hall of Fame 2006