ERB-79
ERB-79 is a synthetic estrogen and a selective agonist of the ERβ. It is a racemic mixture, with the active enantiomer being ERB-26. ERB-79 shows more than 484-fold selectivity for transactivation of the ERβ over the ERα. Its EC50 value for the ERβ is 0.448 nM and for the ERα is 79 nM. It has no antagonistic activity at either receptor. ERB-79 is active in preclinical models of arthritis. The chemical structure of ERB-79 does not appear to have been disclosed.
