. He later became an assistant professor in the Departments of Neurology and Pathology at Harvard Medical School in 1970. A year later, he became an associate professor at Johns Hopkins University where he is now Professor Emeritus. In 1990, he served as the President of American Association of Neuropathologists. From 2000-2001, he served as the President of the Society for Neuroscience. He has also mentored several prominent physicians and investigators at the Johns Hopkins University’s Neuropathology Division to become important leaders in the field of neurobiology of diseases. Some notable physicians and investigators include Carlos Porteria-Cailliau, Naomi E. Rance, Charles White III, David R. Borchet, and Lee J. Martin.
Research
Price first focused on the biology of motor neurons, but later in his career, became more interested in brain mechanisms. He mainly used animal models in order to “allow a more direct insight into pathogenesis” rather than using human models. His particular research interests involve “age-associated neurodegenerative diseases, particularly ”. H. In 1985, he became a Principal Investigator of the Alzheimer’s Disease Research Center at Johns Hopkins University. Eventually he became the director of the center and is now director emeritus.
Alzheimer's Disease
Price’s research has a focus on treatment for neurodegenerative conditions. His work with transgenic mice seeks to experimentally test new treatment mechanisms before they reach human subjects. These studies have identified specific genes that are often risk factors, particularly amyloid-prone genes, and attempted to correlate them to particular behaviors associated with Alzheimer’s disease. For example, his research has concluded that mutations to amyloid precursor proteins are linked to memory loss. Price took part in the publication of the Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology text. He worked with colleagues Philip C. Wong and Tong Li to write a chapter on Alzheimer’s disease and how it causes major defects within the brain. Alzheimer’s disease is one of Price’s most researched topics. Price discovered that the neuroscience of AD is characterized by neuronal loss, the failure of functioning neurons, or the lack of neurofibrillary tangles within parts of the brain. In the publication, he discussed the neurofibrillary tangles and how they were most commonly found in the central superior nucleus. He further described that NFTs help determine the duration of the disease as well. Patients with a longer duration of AD had fewer NFTs than patients with a shorter duration of AD. The number of NFTs in the nuclei inversely reflect the rate of progression; if only a small number of NFTs are found, then the disease progresses slower.
Awards and honors
Publications
The list below are some of his most cited publications :
Personal Life
He and his wife have three children, who all currently practice medicine.
