De Soto
- DESOTO patrol
- De Soto National Forest
- De Soto National Memorial
- De Soto Parish, Louisiana
- De Soto station
- De Soto, Georgia
- De Soto, Illinois
- De Soto, Iowa
- De Soto, Kansas
- De Soto, Mississippi
- De Soto, Missouri
- De Soto, Nebraska
- De Soto, Wisconsin
- DeSoto (automobile)
- DeSoto County, Florida
- DeSoto County, Mississippi
- DeSoto Falls (Alabama)
- DeSoto Falls (Georgia)
- DeSoto Lake
- DeSoto National Wildlife Refuge
- DeSoto Records
- DeSoto Site Historic State Park
- DeSoto, Indiana
- DeSoto, Texas
- Fort De Soto Park
- Hernando de Soto
- Soto (disambiguation)
- The DeSoto
- USS De Soto County (LST-1171)
- de Soto (surname)
