Worley attended the William Penn Charter School and was a standout receiver and safety for head coach Jeff Humble. As a receiver, he earned first-team honors during his junior and senior seasons. As a defensive back, he earned first team honors as a senior. He was an All-Southeastern Pennsylvania First-Team defensive back and 2-time Penn Inter-Ac League First Team football player. He was rated as Southeastern Pennsylvania's top cornerback by the Philadelphia Inquirer coming out of high school.
College career
Daryl Worley attended West Virginia University where he played for the West Virginia Mountaineers from 2013 to 2015. As a freshman, he played in 11 games and started 5 games. He was primarily used on special teams and finished the season with 45 tackles and 1 interception. He was also second on the team with five pass breakups. During his sophomore season, Worley started in all 11 games for the Mountaineers. He led the team with 3 interceptions. He was also the fifth-leading tackler on the team with 52 tackles and also recorded 4 pass breakups. He was named the Iron Mountaineer honoree for excellence in the weight room. His three interceptions tied him for 11th in the Big 12 Conference. During his true junior season, Worley earned 1st-Team All-Big 12 honors after finishing among the nation's leaders with 6 interceptions and 12 pass breakups. He also recorded 49 tackles and forced 2 fumbles on the year. Despite a recommendation from the NFL Draft Advisory Committee to return to school, Worley decided to forgo his final season of eligibility and enter the 2016 NFL Draft.
Professional career
Carolina Panthers
Worley was selected by the Carolina Panthers in the third round. He opened the 2016 NFL season as third on the cornerback depth chart, behind veteran Bené Benwikere and fellow rookie James Bradberry. After Julio Jones had 300 receiving yards over the Carolina Panthers in Week 4 of the NFL season, primarily against Benwikere and Worley, Benwikere was released. This made Bradberry the number one starting cornerback, Worley the number two, and fellow rookie Zack Sanchez the number three. Worley steadily improved throughout the year and finished the season ranked as the twelfth best cornerback against the run by respected analytical site Pro Football Focus.
On March 9, 2018, the Panthers agreed to trade Worley to the Philadelphia Eagles for wide receiverTorrey Smith. The deal became official on March 14, 2018. On April 15, 2018, Worley was released by the Eagles after he was arrested stemming from an altercation with police.
On April 23, 2018, Worley signed with the Oakland Raiders. He was suspended the first four games of 2018 for violating the NFL Policy and Program for Substances of Abuse and the Personal Conduct Policy. In Week 6 against the Seattle Seahawks, Worley made 5 tackles and intercepted quarterback Russell Wilson. He was placed on injured reserve on December 24, 2018. He finished the season playing in 10 games with nine starts, recording 33 tackles, seven passes defensed and one interception. On March 7, 2019, the Raiders placed a second-round restricted free agent tender on Worley. In week 9 against the Detroit Lions, Worley recorded a one handed interception off Matthew Stafford that was intended for wide receiver Kenny Golladay in the endzone during the 31-24 win.