Enos attended Edsel Ford High School in Dearborn, Michigan. He played quarterback and earned all-state honors while passing for 46 touchdowns and compiling 5,743 yards of total offense. Enos played four years at Michigan State University, including two as starting quarterback. Under Enos and then coach George PerlesMichigan State won the 1989 Aloha Bowl and 1990 John Hancock Bowl and took a share of the 1990 Big Ten championship. Enos has the third-best all-time pass completion percentage in Spartan history and eighth-best total yards. In 1991 Enos graduated from Michigan State with a degree in business administration.
Coaching career
After graduation Enos joined the Michigan State footballcoaching staff as a graduate assistant, staying there from 1991 to 1993. In 1994 Enos joined the coaching staff at Lakeland College, a Division III school in Plymouth, Wisconsin. As offensive coordinator, Enos helped develop Mark Novara, Lakeland's most successful quarterback. After Novara entered the Lakeland Athletic Hall of Fame in 2008, he credited Enos for much of his success: "That was Coach Enos' first stint on a coaching staff. He was really young, but really good. We knew he'd be in the Big Ten some day." After two years at Lakeland, Enos moved on to Division IINorthern Michigan University, where he spent a year as offensive coordinator. Enos then spent two years at Southern Illinois as quarterback and wide-receiver coach before being announced to his first Division I offensive coordinator position at Missouri State in 1999 under then-head coach Randy Ball. He then moved to be quarterbacks coach at Western Michigan for three seasons before becoming the offensive coordinator at Division I-FCS school North Dakota State for one season in 2003. He then spent two seasons as quarterbacks coach for Cincinnati before returning again to his alma mater of Michigan State, spending four seasons there split between being quarterbacks and running backs coach.
Central Michigan
On January 12, 2010, Enos was introduced as the head coach at Central Michigan University, replacing Butch Jones, who left after three seasons to replace Brian Kelly at the University of Cincinnati. Enos's teams struggled in his first two seasons at CMU. Enos produced back-to-back 3-9 seasons in 2010 and 2011. Despite the 6-18 record over two seasons, Enos was rewarded with a one-year contract extension in February 2012, extending his deal through the 2015 season. Despite a 2–1 start in 2012 and an upset victoryon the road over the University of Iowa, CMU again struggled under Enos, suffering a four-game losing streak after the upset in Iowa City. CMU suffered a 42–31 loss to rival Western Michigan University which saw CMU get outscored 28-8 in the 4th quarter. The loss was CMU's second straight to Western and CMU's record stood at 3-6. The following Wednesday, Central Michigan Life, published an editorial calling for Enos to be fired. After the Western loss, Enos led CMU to a four-game winning streak and a victory over Western Kentucky in the 2012 Little Caesars Pizza Bowl, CMU's first bowl appearance and win since the 2010 GMAC Bowl. The 4-game winning streak gave CMU a record of 7–6, its first winning record since the 2009 season, the last season under Butch Jones and with Dan LeFevour as starting quarterback. Enos was again rewarded with a one-year contract extension and pay raise in January 2013, extending his deal through the 2016 season. On January 22, 2015, he resigned to take the offensive coordinator position at Arkansas.
After Central Michigan
After resigning his head coaching position at Central Michigan, Enos spent three seasons from 2015 to 2017 as offensive coordinator and quarterbacks coach for Arkansas under then-head coach Bret Bielema. His time as offensive coordinator was highlighted by an 8–5 record and Liberty Bowl win in his first season as offensive coordinator in 2015, the best overall record that Bielema had during his tenure as head coach. Bielema was fired from his position as Arkansas head coach after the 2017 season and new Arkansas head coach Chad Morris chose not to retain Enos, instead opting to bring in his own staff. Enos joined the Michigan staff as an offensive assistant in January 2018. He only stayed for about 6 weeks before leaving. Enos then joined Alabama for the 2018 season as quarterbacks coach under head coach Nick Saban as they finished the season with a perfect 13–0 record and a berth in the Orange Bowl as a part of the 2019 College Football Playoff National Championship. Enos was widely credited with Alabama quarterback Tua Tagovailoa's high completion percentage and passer efficiency rating for the 2018 season. After the season Enos left Alabama and was hired as the offensive coordinator and quarterbacks coach at Miami under head coach Manny Diaz. On December 26, 2019, after a 14–0 shutout loss to Louisiana Tech in the Independence Bowl, Miami parted ways with Enos.