Born in Spain, Larrañaga immigrated through Mexico City to Northern New Mexico. He married María Gertrudiz Mestas and had seven sons and two daughters. In 1804, Larrañaga received a shipment of cowpox scabs from Mexico City and travelled north to Chihuahua City with children to pass the smallpox vaccination from person to person. He continued his travelsup north along the Camino Real to Taos. His logs show he vaccinated 3,610 people. Larrañaga is credited for saving a generation. The children who traveled from Ciudad Chihuahua to Santa Fé with Larrañaga were children of soldiers, and were also labeled as heroes. New Mexico had been struggling against smallpox since the early 1780s; a 1781 outbreak had killed 5,000 people, which is thought to have been more than a quarter of the population in New Mexico. Fray Angélico Chávez states extant orders given to Larrañaga to vaccinate the area until 1809. He also cites Larrañaga as a notary for the state. In 1809, Larrañaga was vaccinating again after running out of antigen. In 1810, he is recorded as vaccinating 124 children up to age six. By the end of that year, he exhausted himself by providing serum to so many. In Saints & Seasons: A Guide to New Mexico's Most Popular Saints, the authors state that "n the annals of New Mexico medicine, Cristóval Larrañaga is both a pioneer and a hero." Simmons states that "Dr. Larrañaga deserves a biographer". He practiced in New Mexico from 1775 to 1811. Larrañaga was the only accredited and trained physician in the territory. The pioneer was responsible for caring for more than forty thousand people. In Tocante a monumentos de españoles, the author Jerry Padilla says that Larrañaga should be honored for his efforts of vaccinating so many. On page 106 of Land Claims in New Mexico, Congressional Edition, Volume 967, Larrañaga signs as secretary of the Corporation of Santa Fé. This was a promotion due to the notaries he facilitated. Larrañaga is mentioned as deserving a promotion due to his extensive knowledge of medicine. Eight Generations of the Larrañaga Family, David H. Salazar. One of the least known persons who made an impact in New Mexico. Salazar provides the first genealogical research on the family Larrañaga. Descendants have served as doctors, served in the military, and served as notaries. Descendants include Larry Larrañaga, a New Mexico State Representative. Larrañaga's work with the smallpox vaccine in New Mexico inspired a children's book, Amadito and the Hero Children.
