He was born in New York, son of Enrique Cristóbal de Losada Plissé and Amalia Natividad Puga y Puga. He was two years old when, in 1896, his father died so he was taken back to Peru and settled in Cajamarca, the land of his mother's family. There he attended his primary and secondary studies. In 1913 he went to Lima to study at the National School of Engineers, obtaining his title of Mining Engineer in 1919. His first professional work was with the Corps of Mining Engineers, until 1923. He was also admitted in the Faculty of Sciences of the National University of San Marcos. In 1922, he graduated with a bachelor's degree and later in 1923 he obtained his diploma as a doctor of mathematical sciences from this institution, with a thesis "On rolling curves". He dedicated himself to teaching. In the Chorrillos Military School he was professor of Arithmetic, Descriptive Geometry and Elemental Mechanics. In the Faculty of Sciences of San Marcos he was Professor of Differential and Integral Calculation, and of Calculation of Probabilities and Mathematical Physics. In the National School of Engineers he was professor of Rational Mechanics, Resistance of Materials and Infinitesimal Calculation, work that exerted until the closing of the School for political reasons. In 1924 he was a speaker at the International Congress of Mathematicians in Toronto. In 1931 he assumed the presidency of the National Society of Industries. In 1933 he became a professor at the Faculty of Science and Engineering at the Pontifical Catholic University of Peru, where he taught Analytical Geometry, Infinitesimal Calculation, Mechanics and Resistance of Materials, until 1953. He became dean of the Faculty and even came to serve as prorector. President José Luis Bustamante y Rivero summoned him to serve as Minister of Public Education, he served in this role from January 12 to October 30, 1947. On July 12, 1948 he was appointed Director of the National Library of Peru, a position in which he remained until his death. During his long period at the head of that institution he directed the Fénix magazine. He was a member of the National Academy of Exact, Physical and Natural Sciences of Peru, of the Peruvian Association for the Progress of Science and of the Peruvian Academy of Language. He was also a member to the Royal Academy of Physical and Natural Sciences of Madrid, the Royal Spanish Mathematical Society, the French Physical Society and the American Mathematical Association of America. He married María Luisa Marrou y Correa, he was the father of five children.