Coker refers to the academic program for the four-year undergraduate degree as the Trans4mations Program, with the first year being foundational, the second year requiring service and attendance at cultural events, the third year requiring at least two weeks of study off-campus, and the final year called a "capstone". The Liberal Arts Studies Program is divided into Core Skills, Knowledge of the Arts, Knowledge of the Behavioral Sciences, Knowledge of the Humanities, Knowledge of the Natural Sciences, Knowledge of the United States, and Knowledge of the Wider World. Coker offers 29 majors and 23 minors of study. The college also offers individual majors and double majors, self-designated degree programs, specializations and pre-professional programs.
The main campus contains mostly Georgian-style brick buildings, some of which are listed on the National Register of Historic Places. The Alumni House, The President's House, The Dean's and President's Offices and The Registrar's Offices are all located in old mansions along the northern edge of campus. Hartsville and Coker University owe much to the generosity of the Coker family, founders of Sonoco and Coker's Pedigreed Seed Company. The Coker family's patronage of the college has led to the vast majority of buildings on campus having Coker somewhere in the name. Students often joke to freshmen or visitors that they'll meet them "in the Coker" building as a way to gently initiate newcomers to campus.
Residence halls
On-campus residence halls include Memorial, Belk, Coker and Grannis, which all adjoin the Linville Dining Hall. Richard and Tuck Coker Hall, commonly called the RTC, and James Lide Coker III occupy separate buildings near Memorial Hall. Most of the older residence halls have been remodeled since 2005 and are fully modernized. A new residence hall, the Betty Y. and Charles L. Sullivan Jr. Residence Hall at The Village at Byerly Place, opened in 2013. In 2011, Coker opened the Coker Downtown Lofts and in 2012 the Downtown Flats, both located just off campus in downtown Hartsville. The Dining Hall, with services provided by Sodexo, offers cafeteria-style dining with several options at each meal. Memorial Hall houses the Drawing Room, a ballroom/dining hall for special events.
Library
In January 2008, students began using the Charles W. and Joan S. Coker Library-Information Technology Center. The new library was built entirely from donations from a capital campaign and is an example of Coker alumni generosity to the college. The former James Lide Coker Memorial Library is now James Lide Coker Memorial Residence Hall.
Sports
Adjacent to the main campus is a 22-acre athletics complex with baseball, softball, soccer and tennis facilities. Near the athletics complex is the DeLoach Center, which contains a 1,908 seat gymnasium, an auxiliary gym, interactive classrooms, a student-athlete only weight room, a fitness center, athletic offices and more. The college has 21 varsity athletics programs, which compete in The South Atlantic Conference. They include Women's Basketball, Men's Basketball, Baseball, Softball, Women's Volleyball, Men's Lacrosse, Women's Lacrosse, Women's Tennis, Men's Tennis, Women's Golf, Men's Golf, Women's Soccer, Men's Soccer, Women's Field Hockey, Women's Cross Country, Men's Cross Country, Women's Track and Field, Men's Track and Field, and Wrestling. In the 2013 season the Coker baseball team won the Conference Carolinas Tournament title, earned the team's first-ever postseason bid, won the NCAA Southeast Regional and advanced to the NCAA DII Baseball National Championship. They finished the year with a record of 38–16.