Claude was born in Fontainebleau, but as she was believed to have been conceived at Chateau d'Anet, she was nicknamed as 'Mademoiselle d'Anet' at court, a nickname that displeased her mother. Claude was raised alongside her sister Elisabeth, and her future sister-in-law, Mary, Queen of Scots. The royal children were raised under the supervision of the governor and governess of the royal children, Jean d'Humières and his wife Françoise d'Humières, under the orders of Diane de Poitiers. Claude was victim of the unhealthy traits that Catherine appeared to pass on to all her children with the exception of Marguerite, and suffered from a hunchback and a club foot, and during her childhood she was frequently vulnerable to various child diseases. On 19 January 1559, at the age of 11, she married Charles III, Duke of Lorraine in the cathedral of Notre Dame in Paris. The marriage was arranged as a symbolic union of peace between France and Lorraine, after Charles III had spent his childhood as a hostage at the French royal court, and completed after the Treaty of Chateau-Cambresis. Claude departed to Lorraine with her spouse in late 1559, shortly before the departure of her sister Elisabeth to Spain and her aunt Marguerite to Savoy.
Duchess of Lorraine
The relationship between Claude and Charles III was described as a happy one. Claude was a favorite of her mother, who occasionally visited her in Lorraine, visits described as rare occasions of private family gatherings in the life of Catherine de Medici, who enjoyed to see her grandchildren by Claude and also liked her son-in-law Charles very much. Catherine de Medici was, for example, present in Bar-le-Duc for the baptism of Claude's firstborn son Henry. Claude attended the wedding between Henry of Navarre and her sister Margaret of Valois in Paris in August 1572. On her way there, she had been ill and cared for by her mother in Chalons, which was the reason why Catherine de Medici had been absent from the royal court during the border attack of Jean de Genlis near the Spanish Netherlands in July, which was used by Admiral Coligny to attempt to convince Charles IX to declare war on Spain. On evening of the Massacre, Claude was evidently informed that a massacre was to take place against the groom of her sister and his followers, and Margaret of Valois described how Claude had tears in her eyes and tried to stop her from leaving their mother's chamber, when Margaret was about to retire to the chamber of her spouse. Claude took Margaret's arm and begged her not to leave: she was contradicted by their mother, who warned Claude not to tell Margaret anything. Claude told their mother that it was not right to send Margaret to be "sacrificed", as she would risk becoming a target, but Catherine de Medici replied to Claude that Margaret would be safe if God wished it, that it would arouse suspicion if she did not go, and then told Margaret to leave, upon which Claude cried. After the massacre started, one of the courtiers of Navarre, de Leran, broke into the bedchamber of Margaret and begged her to save him from the captain of the Guards, M. de Nancay, who gave her the man's life, and then escorted her to the chamber of Claude, where she was given refuge during the massacre. During the last of her frequent visits to the French court, her brother the king gave her the gift of "the ransoms of Guyenne, which came from the confiscations that took place there", and in turn gave one of the ransoms to Jeanne de Dampierre when asked. Brantôme gave the following description of her: Claude died in childbirth in 1575 at the age of 27. Brantôme wrote that she "died in child-bed, through the appetite of an old midwife of Paris, a drunkard, in whom she had more faith than in any other."
